Evaluation of the toxicity and reversibility profile of the aqueous seed extract of Hunteria umbellata (K.Schum) Hallier F. in rodents

Bibliographic Data

ID20346359
AuthorsAA Adeneye (Lagos State University), OO Adeyemi, EO Agbaje, AAF Banjo
Year2010
Volume7
Issue4
Pages350-69
Publication date2010-07-16
Open AccessYes
TypeARTICLE
VenueAfrican Journal of Traditional Complementary and Alternative Medicines (JOURNAL)
Journal identifiersISSN: 0189-6016 • E-ISSN: 2505-0044
PublisherAfrican Journals Online (AJOL) (PUBLISHER)
DOI10.4314/ajtcam.v7i4.56704
PMID21731167
OpenAlexW2111534478
LanguageEN
Citations received3
References cited6

Hunteria umbellata (K. Schum.) Hallier f. (family: Apocynaceae) is reputed for the folkloric management of labour, pain and swellings, stomach ulcers, diabetes, obesity, and anaemia, with no scientific report of its toxicity and reversibility profile. The present study was, therefore, aimed at investigating the in vivo toxicity and reversibility profile of the aqueous seed extract of Hunteria umbellata (HU). The acute oral and intraperitoneal toxicity studies of HU were determined in Swiss albino mice while its 90-day oral toxicity and toxicity reversibility profile on anthropometric, biochemical, haematological and histopathological parameters were also assessed using standard procedures. Results showed that the LD50 values for the acute oral and intraperitoneal toxicity studies for HU were estimated to be 1000 mg/kg and 459.3 mg/kg, respectively. Visible signs of immediate and delayed toxicities including starry hair coat, respiratory distress, and dyskinesia were observed. For the chronic oral toxicity study, HU administered for 90 days produced significant (p 0.05) alterations in the serum levels of sodium, potassium, alaninine transaminase, aspartate transaminase, alkaline phosphatase, total and conjugated bilirubin, total protein and albumin. Also, chronic oral treatment with HU produced significant (p 0.05) reversal in the serum levels of the biochemical and haematological parameters investigated, including the HU-induced histological lesions. Overall, results of this study showed that HU has a relatively low oral toxicity profile but its prolonged use, particularly, at high doses should be with great caution

Acute toxicity · Alkaline phosphatase · Aspartate transaminase · Chronic toxicity · Median lethal dose · Toxicity · Chemistry · Medicine · Pharmacological Effects of Natural Compounds · Phytochemistry and Bioactive Compounds · Phytochemistry and biological activities of Ficus species · Biochemistry · Internal Medicine · Pharmacology

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