Effects of Salvia Miltiorrhizae on the Kidney of Rats With Severe Acute Pancreatitis and Obstrutive Jaundice
Bibliographic Data
| ID | 20346705 |
|---|---|
| Authors | Ren Guibing (Logistics University of People's Armed Police Force), Zhang Xiping, Xiping Zhang (0000-0002-4239-2853, Wenzhou Medical University), Ding Xiaowen, Ding Xiao-wen (Zhejiang Cancer Hospital), Zou Dehong (Zhejiang Cancer Hospital), Yang Hongjiang (Zhejiang Cancer Hospital), Meng Xiaoru (Logistics University of People's Armed Police Force), Mo Wenju (Zhejiang Cancer Hospital), He Xiangming (Zhejiang Cancer Hospital), Zhao Shuai (Zhejiang Cancer Hospital) |
| Year | 2017 |
| Volume | 14 |
| Issue | 2 |
| Pages | 103-124 |
| Publication date | 2017-01-13 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER) |
| DOI | 10.21010/ajtcam.v14i2.12 |
| PMID | 28573227 |
| OpenAlex | W2591902192 |
| Language | EN |
| Citations received | 1 |
| References cited | 1 |
Background: Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are frequent recurring diseases that bring about huge threat to human health. Some reports have demonstrated that Salviae miltiorrhizae can protect multiple organs of SAP and OJ model animals or patients, but their related mechanisms were not clear. In this study, we observed the effects of Salvia miltiorrhizae injection on apoptosis and NF-κB expression in kidney and explored the protective effect and mechanism of Salvia miltiorrhizae on the kidney of SAP or OJ rats. The results obtained will provide a theoretical basis for clinical application of Salvia miltiorrhizae. Material and Methods: A total of 288 rats were used for SAP - and OJ-associated experiments. The mortality rates of rats, the contents of serum BUN and CREA, the expression levels of Bax, NF-κB proteins and the apoptosis index were observed, respectively. Results: The pathological changes in the kidney of SAP or OJ rats in treated group were mitigated to varying degrees. At 6 and 12 hours after operation in SAP rats or on 21 and 28 days after operation in OJ rats, the contents of serum CREA in treated group were significantly lower than those in model control group; At 3 and 6 hours after operation, the staining intensity of Bax protein of kidney in treated group was significantly lower than that in model control group; on 14 days after operation, the apoptosis index in the kidney of OJ rats in treated group was significantly lower than that in model control group. Conclusion: Salvia miltiorrhizae can exert protective effects on the kidney of SAP and OJ rats
Acute pancreatitis · Apoptosis · Biology · Jaundice · Kidney · Obstructive jaundice · Pancreatitis · Pathological · Pathology · Salvia · Salvia miltiorrhiza · Traditional Chinese medicine · Traditional medicine · Medicine · Pancreatitis Pathology and Treatment · Paraoxonase enzyme and polymorphisms · Streptococcal Infections and Treatments · Biochemistry · Endocrinology · Gastroenterology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.11 |
| Citation span | 2017 - 2017 (1) |
| Citation velocity | historical |
| Highly cited | No |