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The dichloromethane fraction from Calotropis gigantea (L.) dryand. Stem bark extract prevents liver cancer in SDT rats with insulin-independent diabetes mellitus

Bibliographic Data

ID21094091
AuthorsThaiyawat Haewphet (Naresuan University), Supawadee Parhira (0000-0002-2077-5888, Naresuan University), Pattaraporn Chaisupasakul (0000-0002-1062-5843, Naresuan University), Apirath Wangteeraprasert (0000-0001-7592-5436, Naresuan University), Ittipon Phoungpetchara (0000-0001-7251-1895, Naresuan University), Dumrongsak Pekthong (0000-0001-8965-3435, Naresuan University), Worasak Kaewkong (0000-0002-7130-5827, Naresuan University), Zhi-Hong Jiang, Zhi‐Hong Jiang (0000-0002-7956-2481, Macau University of Science and Technology), Li-Ping Bai (0000-0002-2806-6883, Macau University of Science and Technology), Julintorn Somran (0000-0001-7158-0928, Naresuan University, corresponding author), Piyarat Srisawang (0000-0002-0948-8239, Naresuan University, corresponding author)
Year2024
Volume334
Pages118516
Publication date2024-11-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118516
PMID38971341
OpenAlexW4400321184
LanguageEN
Citations received1
References cited123

These findings suggest that C. gigantea stem bark extract exerts preventive effects against the development of HCC complications in patients with T2DM, expanding the potential benefits of its ethnopharmacological advantages

Alternative medicine · Biological activity · Biology · Cancer · Diabetes mellitus · Dichloromethane · In vitro · Insulin · Liver cancer · Pathology · Pharmacognosy · Phytotherapy · Traditional medicine · Chemistry · Medicine · Metabolism, Diabetes, and Cancer · Natural Antidiabetic Agents Studies · Phytochemistry and Bioactive Compounds · Biochemistry · Endocrinology · Internal Medicine

  • Calotropis gigantea (L.) Dryand. Stem bark extract suppresses tumor angiogenesis through modulation of HIF-1α/Vegf signaling and ERK1/2-AKT activation in HepG2 xenograft-bearing nude mice

    Open Access•Aylada Kaenu, Pholawat Tingpej et al.•Journal of Ethnopharmacology•2026

  • Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

    Open Access•Kenneth J Livak, Thomas D Schmittgen•Methods•2001

  • IDF Diabetes Atlas

    Open Access•Hong Sun, Pouya Saeedi et al.•Diabetes Research and Clinical…•2022

  • Phytochemical analysis, anti-inflammatory, antioxidant activity of Calotropis gigantea and its therapeutic applications

    Open Access•Sreewardhini Sivapalan, Sankari Dharmalingam et al.•Journal of Ethnopharmacology•2023

  • Cardenolides from Calotropis gigantea as potent inhibitors of hypoxia-inducible factor-1 transcriptional activity

    Open Access•Supawadee Parhira, Guo-Yuan Zhu et al.•Journal of Ethnopharmacology•2016

  • An ethnobotanical survey of medicinal plants used in Terai forest of western Nepal

    Open Access•Anant Gopal Singh, Akhilesh Kumar et al.•Journal of Ethnobiology and…•2012

Citations per year1
Citation span2026 - 2026 (1)
Highly citedNo

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