Annual Research Review

The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses

Bibliographic Data

ID21344351
AuthorsJennifer Pacheco (0009-0006-0848-518X, Division of Translational Research National Institute of Mental Health Bethesda MD USA), Marjorie A Garvey (0000-0002-0985-979X, Division of Translational Research National Institute of Mental Health Bethesda MD USA), Christopher S Sarampote (Division of Translational Research National Institute of Mental Health Bethesda MD USA), Elan D Cohen (0000-0003-4598-2709, Office of Science Policy, Planning, and Communications National Institute of Mental Health Bethesda MD USA), Eric R Murphy (0000-0002-5002-3898, Division of Translational Research National Institute of Mental Health Bethesda MD USA), Stacia R Friedman‐Hill (Division of Translational Research National Institute of Mental Health Bethesda MD USA)
Year2022
Volume63
Issue4
Pages360-376
Publication date2022-04-01
Open AccessYes
TypeARTICLE
VenueJournal of Child Psychology and Psychiatry (JOURNAL)
Journal identifiersISSN: 0021-9630 • E-ISSN: 1469-7610
PublisherWiley (PUBLISHER • GB)
DOI10.1111/jcpp.13543
PMID34979592
OpenAlexW4205236099
LanguageEN
Citations received5
References cited103

The National Institute of Mental Health (NIMH) proposed the Research Domain Criteria (RDoC) initiative as an alternate way to organize research of mental illnesses, by looking at dimensions of functioning rather than being tied to categorical diagnoses. This paper briefly discusses the motivation for and organization of RDoC, and then explores the NIMH portfolio and recent work to monitor the utility and progress that RDoC has afforded developmental research. To examine how RDoC has influenced the NIMH developmental research portfolio over the last decade, we employed a natural language processing algorithm to identify the number of developmental science grants classified as incorporating an RDoC approach. Additional portfolio analyses examine temporal trends in funded RDoC‐relevant grants, publications and citations, and research training opportunities. Reflecting on how RDoC has influenced the focus of grant applications, we highlight examples from research on Attention‐Deficit Hyperactivity Disorder (ADHD), childhood irritability, and Autism Spectrum Disorder (ASD). Lastly, we consider how the dimensional and transdiagnostic approaches emphasized in RDoC have facilitated research on personalized intervention for heterogeneous disorders and preventive/early interventions targeting emergent or subthreshold psychopathology

Autism · Autism spectrum disorder · Mental health · Psychiatry · Psychological intervention · Research Domain Criteria · Attention Deficit Hyperactivity Disorder · Bipolar Disorder and Treatment · Functional Brain Connectivity Studies · Psychology

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Open DOIOpen Access