Hair Cortisol Concentrations in the Prediction of Early Substance Use Engagement in Youth
Bibliographic Data
| ID | 21646728 |
|---|---|
| Authors | Anastasia Georgiades (0000-0003-1937-7601, Duke University, corresponding author), Jennifer Godwin (0000-0001-5258-1351, Duke University), Fabio Cavalcante Andrade (0000-0002-4862-3544, Duke University), William Copeland (0000-0002-1348-7781, Duke University), Erin K Davisson (0000-0002-9061-3948, Duke University), Cynthia M Kuhn (0000-0001-6131-1839, Duke University), Kaitlyn Burnell (0000-0003-0959-6632, University of North Carolina at Chapel Hill), Rick H Hoyle (0000-0003-0900-2814, Duke University) |
| Year | 2025 |
| Volume | 60 |
| Issue | 2 |
| Pages | 244-256 |
| Publication date | 2025-01-28 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Substance Use & Misuse (JOURNAL) |
| Journal identifiers | ISSN: 1082-6084 • E-ISSN: 1532-2491 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/10826084.2024.2423366 |
| PMID | 39529366 |
| OpenAlex | W4404289952 |
| Language | EN |
| References cited | 85 |
Objective Understanding factors associated with early onset of substance use is critical as using alcohol or drugs at a young age is a strong predictor of later substance dependency. Experiencing stressful life events is associated with increased risk for early substance use in youth. Hair cortisol concentration (HCC) is considered a biomarker of psychological stress experienced over longer periods of time. We examined whether HCC could predict early substance use engagement in youth followed over 5 years.Methods Participants were 395 young adolescents (50% female, age range 10-15 years, Mage = 12.3, SD = 1.1 at baseline). Demographic data, socioeconomic factors, and substance use habits were collected at four waves between 2015 and 2021. HCC was assayed from hair collected at a home visit between Wave 1 and Wave 2. Analytic models tested a) HCC in relation to latent class membership of substance use and b) whether HCC moderated the relation between self-reports of stress and substance use.Results HCC did not add to the prediction of early substance use engagement in any of the models, while self-reports of stressful life events and everyday discrimination predicted early substance use engagement in the models comparing ‘Early’ vs ‘Late/No’ substance use class membership.Conclusion We found no evidence of HCC to be associated with early substance use engagement in youth. Nevertheless, our results do confirm that self-reports of stressful everyday life experiences predict earlier substance use engagement, underscoring the role of psychosocial stressors as significant predictors of substance use engagement in youth
Developmental psychology · Psychiatry · Substance use · Clinical Psychology · Neurotransmitter Receptor Influence on Behavior · Psychology · Stress Responses and Cortisol · Substance Abuse Treatment and Outcomes
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| Citation velocity | historical |
|---|---|
| Highly cited | No |