The effects of social isolation stress and discrimination on mental health
Bibliographic Data
| ID | 23319355 |
|---|---|
| Authors | Lasse Brandt (0000-0002-6873-9894, Charité - Universitätsmedizin Berlin), Shuyan Liu (0009-0002-2549-5954, Charité - Universitätsmedizin Berlin), Christine Heim (0000-0003-4716-9316, Charité - Universitätsmedizin Berlin), Andreas Heinz (0000-0001-5405-9065, Charité - Universitätsmedizin Berlin, corresponding author) |
| Year | 2022 |
| Volume | 12 |
| Issue | 1 |
| Pages | 398-398 |
| Publication date | 2022-09-21 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Translational Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 2158-3188 • E-ISSN: 2158-3188 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/s41398-022-02178-4 |
| PMID | 36130935 |
| OpenAlex | W4296692877 |
| Language | EN |
| Citations received | 63 |
| References cited | 187 |
Social isolation and discrimination are growing public health concerns associated with poor physical and mental health. They are risk factors for increased morbidity and mortality and reduced quality of life. Despite their detrimental effects on health, there is a lack of knowledge regarding translation across the domains of experimental research, clinical studies, and real-life applications. Here, we review and synthesize evidence from basic research in animals and humans to clinical translation and interventions. Animal models indicate that social separation stress, particularly in early life, activates the hypothalamic-pituitary-adrenal axis and interacts with monoaminergic, glutamatergic, and GABAergic neurotransmitter systems, inducing long-lasting reductions in serotonin turnover and alterations in dopamine receptor sensitivity. These findings are of particular importance for human social isolation stress, as effects of social isolation stress on the same neurotransmitter systems have been implicated in addictive, psychotic, and affective disorders. Children may be particularly vulnerable due to lasting effects of social isolation and discrimination stress on the developing brain. The effects of social isolation and loneliness are pronounced in the context of social exclusion due to discrimination and racism, during widespread infectious disease related containment strategies such as quarantine, and in older persons due to sociodemographic changes. This highlights the importance of new strategies for social inclusion and outreach, including gender, culture, and socially sensitive telemedicine and digital interventions for mental health care.
Isolation (microbiology) · Mental health · Psychiatry · Psychotherapist · Schizophrenia (object-oriented programming) · Social isolation · Social stress · Stress (linguistics) · Clinical Psychology · Employment and Welfare Studies · Health disparities and outcomes · Psychology · Racial and Ethnic Identity Research
Isolation as a Mechanism of Control
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Gendered Disparities of Subjective Wellbeing and Community Connection Among Vietnamese Migrant Women
Diverse community perspectives on public health guidelines for social connection
Mental health symptoms and discrimination among immigrant and US-born Hispanic or Latino adults during the Covid-19 pandemic
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Validation of a composite outcome measure for inpatient psychiatry using scales from the interRAI-MH
Work-Related Triggers of Mental Illness Relapse in South African Teachers
Low Motor Dexterity and Significant Behaviors Following Hospitalized Isolation in Children
The Roles of Anxiety and Depressive Symptoms in the Relationship Between School Bullying Victimization and Suicidal Ideation Among South Korean College Students
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Examining the multidimensional structure of stress among international medical students
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Does internet use promote the health of empty-nest older adults in rural China? The mediating role of social participation using a propensity score matching approach
The impact of bidirectional emotional support on social isolation in older adults
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Characterizing Social Connectedness and Associated Mental Health Symptoms among Sexual Minority Men Enrolled in a Substance Use Recovery Support Program
A battle for validation and understanding of people with functional neurological disorder (FND)
Treating the Cycle of Social Isolation and Substance Misuse in Young Adults
Social disconnectedness in psychosis
New York City Faith-Based Leaders’ Views on Covid-19’s Impact on the Mental Health Needs of Black/African American Communities
Socio-cultural context of self-harming tendencies
Long-Term Effects of Maternal and Paternal Emotional Distress, Eating, and Body Image on Children’s Weight
Family dynamics and psychological wellbeing of South Asian migrant youth in Australia
The Memory-Masturbation Link
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Examining Spiritual Well-Being as a Protective Factor Against Suicidality in Black Women Dealing with Everyday Discrimination
Is it the place or the people in the places? Exploration of why young people in deprived coastal communities of England have worse mental health than their peers inland
Mental health vulnerability in multicultural families
Racial Discrimination and Its Effects on Hypertension and Healthcare Access Among African Americans
A rural state of mind
Cross-cultural challenges of international Women students in navigating harassment and gendered norms
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Serious psychological distress, unmet mental health treatment needs, and help-seeking among Asian American adults in New York City
Research on the usage intention of aging-friendly smart mobility services based on behavioral reasoning theory
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The link between childhood trauma and depression
Global age-sex-specific fertility, mortality, healthy life expectancy (Hale), and population estimates in 204 countries and territories, 1950–2019
Mental health status of people isolated due to Middle East Respiratory Syndrome
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Perceived social isolation and cognition
The Predictive Coding Account of Psychosis
Mental health effects of infection containment strategies
Evidence for effective interventions to reduce mental-health-related stigma and discrimination
The growing problem of loneliness
An overview of systematic reviews on the public health consequences of social isolation and loneliness
Discrimination in health care against people with mental illness
Perceived racism and mental health among Black American adults
Effects of stress throughout the lifespan on the brain, behaviour and cognition
The effectiveness of nudging
The Neuroendocrinology of Social Isolation
Social relationships and risk of dementia
The neural basis of drug craving
“More than skin deep”
Schizophrenia and Migration
The association between social relationships and depression
Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Disease 2019 (Covid-19) Outbreak in January 2020 in China
Psychological impact of the 2015 Mers outbreak on hospital workers and quarantined hemodialysis patients
Effects of maltreatment on coping and emotion regulation in childhood and adolescence
Income inequality and depression
A Meta-Analysis of Interventions to Reduce Loneliness
Vigilance in the discrimination-stress model for Black Americans
Prevalence of psychological morbidities among general population, healthcare workers and Covid-19 patients amidst the Covid-19 pandemic
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Stigma
Loneliness and Health in Older Adults
Bidirectional associations between Covid-19 and psychiatric disorder
Empirical Studies of Self-Stigma Reduction Strategies
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The relevance of psychosocial variables and working conditions in predicting nurses’ coping strategies during the Sars crisis
Stress and Cardiovascular Disease
Mental health outcomes of quarantine and isolation for infection prevention
Loneliness and cognitive function in the older adult
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Influences of socioeconomic status, social network, and competence on subjective well-being in later life
The Impact of Racism on Child and Adolescent Health
The Biological Concept of Race and Its Application to Public Health and Epidemiology
Interventions to reduce discrimination and stigma
Predictive factors of psychological disorder development during recovery following Sars outbreak.
The psychological impact of quarantine and how to reduce it
Structural racism and health inequities in the USA
Rapid Systematic Review
Loneliness and Social Isolation as Risk Factors for Mortality
Racism as a Determinant of Health
Loneliness among people with substance use problems
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Forensic practitioners’ expectations and moral views regarding neurobiological interventions in offenders with mental disorders
Factors influencing psychological distress during a disease epidemic
Migration, social mobility and common mental disorders
Social isolation, loneliness and health in old age
Income inequality and health
Loneliness and alcohol abuse
A systematic review of studies examining the relationship between reported racism and health and wellbeing for children and young people
Prevalence of alcohol and tobacco use among Brazilian adolescents
The consequences of perceived discrimination for psychological well-being
Perceived discrimination and health
The assessment, monitoring, and enhancement of treatment fidelity in public health clinical trials
Social Capital and Loneliness Among the Very Old Living at Home and in Institutional Settings
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Discrimination and Health Inequities
Racism and Health I
Structural Racism and Health Inequities
| Unique citing works | 63 |
|---|---|
| Citations per year | 21 |
| Citation span | 2023 - 2026 (4) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 60 |