Clinical Significance of High Expression of tRF-Glu-TTC-2 in Prostate Carcinoma and its Effect on Growth
Bibliographic Data
| ID | 21748514 |
|---|---|
| Authors | Lei Wang (0000-0001-5326-565X, Dalian Medical University), Yaxin Liu (0009-0003-5814-6168, Yangzhou University), Wenqing Yan (0000-0002-5405-4026, Yangzhou University), Caihong Huang (0009-0002-0419-7114, Yangzhou University), Zhiyan Ding (Yangzhou University), Jiajia Yang (0000-0001-7521-9814, Yangzhou University), Shuwan Jiang (Yangzhou University), Lei Sun (0000-0003-0096-7804, Dalian Medical University, corresponding author) |
| Year | 2022 |
| Volume | 16 |
| Issue | 6 |
| Pages | 15579883221135970-15579883221135970 |
| Publication date | 2022-11-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Men s Health (JOURNAL) |
| Journal identifiers | ISSN: 1557-9883 • E-ISSN: 1557-9891 |
| Publisher | SAGE Publications (PUBLISHER • US) |
| DOI | 10.1177/15579883221135970 |
| PMID | 36377736 |
| OpenAlex | W4309185774 |
| Language | EN |
| References cited | 20 |
The tRNA-derived fragments (tRFs) are a new class of regulatory noncoding RNAs and have different biological functions in cancer. This article investigated the expression and clinicopathological significance of tRF-Glu-TTC-2 in prostate carcinoma (PCa), and its effect on tumor growth. Expression profiles of tRFs and tiRNAs were analyzed by tRF and tiRNAs microarray in PCa samples, and then the expression was confirmed by qRT-PCR; RNA in situ hybridization was used to detect the positive expression of tRF-Glu-TTC-2 and to analyze the correlation between the expression level of tRF-Glu-TTC-2 and clinicopathological parameters. CCK-8 experiment was used to detect the effect of tRF-Glu-TTC-2 on the proliferation of PCa cells, and nude mice subcutaneous tumor model was used to detect the effect of tRF-Glu-TTC-2 on the growth of PCa cells. The results showed that tRF-Glu-TTC-2 was mainly positive and its expression level increased in PCa. The high expression was closely related to the tumor size ( p
Biology · Cancer · Cell growth · Gene · Gene knockdown · In situ hybridization · Messenger RNA · Prostate · Prostate cancer · Cancer-related molecular mechanisms research · RNA and protein synthesis mechanisms · RNA modifications and cancer · Biochemistry · Cancer Research · Genetics · Molecular Biology
| Highly cited | No |
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