Hirudin-Based Treatment of Diabetes-Induced Erectile Dysfunction Through Inhibition of the HIF-1α to Regulate RhoA/Rock Signaling Pathway
An In Vivo Animal Experiment
Bibliographic Data
| ID | 21748604 |
|---|---|
| Authors | Longji Sun (0000-0001-9841-5156, Beijing University of Chinese Medicine), Nianwen Huang (0009-0009-4788-9330, Beijing University of Chinese Medicine), Chao Yang (0000-0003-3623-4311, Beijing University of Chinese Medicine), Junlong Feng (0009-0000-6915-7784, Beijing University of Chinese Medicine), Hui Chen (0000-0003-2866-7811, Beijing University of Chinese Medicine), Weidong Feng (0009-0007-1557-7194, Beijing University of Chinese Medicine), Zixiang Gao (0000-0002-4345-8201, Beijing University of Chinese Medicine), Bin Wang (0000-0002-8591-8528, Beijing University of Chinese Medicine), Jisheng Wang (0000-0002-3332-076X, Beijing University of Chinese Medicine, corresponding author) |
| Year | 2025 |
| Volume | 19 |
| Issue | 1 |
| Pages | 15579883241310763-15579883241310763 |
| Publication date | 2025-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Men s Health (JOURNAL) |
| Journal identifiers | ISSN: 1557-9883 • E-ISSN: 1557-9891 |
| Publisher | SAGE Publications (PUBLISHER • US) |
| DOI | 10.1177/15579883241310763 |
| PMID | 39936394 |
| OpenAlex | W4407412834 |
| Language | EN |
| References cited | 27 |
Diabetes-induced erectile dysfunction (DIED) is a type of refractory erectile dysfunction which can be clinically treated using the traditional Chinese medicine leech whose main ingredient is hirudin. Oxidative stress can damage vascular endothelial cells, affect blood circulation, and induce fibrosis of smooth muscle cells. This study assessed the efficacy of hirudin in treating DIED before exploring its potential mechanism of action. DIED was induced in rats using streptozotocin, while experimental apomorphine was used to screen for erectile dysfunction models. The rats were then divided into four groups: a blank control group (NC group), a model group (M group), a hirudin group (H group), and an inhibitor group (YC group). After 2 weeks, the serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) were determined. The histological features and HIF-1α/RhoA/ROCK signaling pathway-related proteins of the penile corpus cavernosum were detected. Erectile function improved in the H and YC groups without significantly affecting body weight and blood glucose levels, with histopathological analysis also showing improvement in penile structure in these groups. In addition, the expression of HIF-1α/RhoA/ROCK signaling pathway-related proteins was lower in the penile cavernous tissue of rats in the H and YC groups ( p
Diabetes mellitus · Erectile dysfunction · Erectile tissue · Hirudin · Malondialdehyde · Nitric oxide · Oxidative stress · RHOA · Signal transduction · Streptozotocin · Superoxide dismutase · Thrombin · Chemistry · Hormonal and reproductive studies · Medicine · Pain Mechanisms and Treatments · Sexual function and dysfunction studies · Biochemistry · Endocrinology · Internal Medicine · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |