The global and regional burden of genital ulcer disease due to herpes simplex virus
A natural history modelling study
Bibliographic Data
| ID | 21880474 |
|---|---|
| Authors | Katharine J Looker (0000-0002-3375-0807, University of Bristol), Christine Johnston (0000-0002-3954-0405, University of Washington), Nicky J Welton (0000-0003-2198-3205, University of Bristol), Charlotte James (0000-0003-4850-5318, University of Bristol), Peter Vickerman (0000-0002-8291-5890, University of Bristol), Katy Turner (0000-0002-8152-6017, At Bristol), Katherine M E Turner (Bristol Veterinary School, University of Bristol, Bristol, UK), Marie-Claude Boily (0000-0003-3919-006X, Imperial College London), Sami L Gottlieb (0000-0003-4398-3441, World Health Organization - Pakistan) |
| Year | 2020 |
| Volume | 5 |
| Issue | 3 |
| Pages | e001875 |
| Publication date | 2020-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | BMJ Global Health (JOURNAL) |
| Journal identifiers | ISSN: 2059-7908 • E-ISSN: 2059-7908 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/bmjgh-2019-001875 |
| PMID | 32201620 |
| OpenAlex | W3011206473 |
| Language | EN |
| Citations received | 3 |
| References cited | 98 |
Introduction: Herpes simplex virus (HSV) infection can cause painful, recurrent genital ulcer disease (GUD), which can have a substantial impact on sexual and reproductive health. HSV-related GUD is most often due to HSV type 2 (HSV-2), but may also be due to genital HSV type 1 (HSV-1), which has less frequent recurrent episodes than HSV-2. The global burden of GUD has never been quantified. Here we present the first global and regional estimates of GUD due to HSV-1 and HSV-2 among women and men aged 15-49 years old. Methods: We developed a natural history model reflecting the clinical course of GUD following HSV-2 and genital HSV-1 infection, informed by a literature search for data on model parameters. We considered both diagnosed and undiagnosed symptomatic infection. This model was then applied to existing infection estimates and population sizes for 2016. A sensitivity analysis was carried out varying the assumptions made. Results: We estimated that 187 million people aged 15-49 years had at least one episode of HSV-related GUD globally in 2016: 5.0% of the world's population. Of these, 178 million (95% of those with HSV-related GUD) had HSV-2 compared with 9 million (5%) with HSV-1. GUD burden was highest in Africa, and approximately double in women compared with men. Altogether there were an estimated 8 billion person-days spent with HSV-related GUD globally in 2016, with 99% of days due to HSV-2. Taking into account parameter uncertainty, the percentage with at least one episode of HSV-related GUD ranged from 3.2% to 7.9% (120-296 million). However, the estimates were sensitive to the model assumptions. Conclusion: Our study represents a first attempt to quantify the global burden of HSV-related GUD, which is large. New interventions such as HSV vaccines, antivirals or microbicides have the potential to improve the quality of life of millions of people worldwide
Disease · Genital herpes · Genital ulcer · Herpes simplex virus · Natural history · Sexually transmitted disease · Syphilis · Virus · Cytomegalovirus and herpesvirus research · Herpesvirus Infections and Treatments · Medicine · Reproductive tract infections research · Immunology · Internal Medicine · Virology
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| Unique citing works | 3 |
|---|---|
| Citations per year | 0,75 |
| Citation span | 2022 - 2024 (3) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 3 |