Socioeconomic risk markers of congenital Zika syndrome
A nationwide, registry-based study in Brazil
Bibliographic Data
While it is well known that socioeconomic markers are associated with a higher risk of arbovirus infections, research on the relationship between socioeconomic factors and congenital Zika syndrome (CZS) remains limited. This study investigates the relationship between socioeconomic risk markers and live births with CZS in Brazil. We conducted a population-based study using data from all registered live births in Brazil (Live Births Information System) linked with the Public Health Event Record from 1 January 2015 to 31 December 2018. We used logistic regression models to estimate the OR and 95% CIs of CZS based on a three-level framework. In an analysis of 11 366 686 live births, of which 3353 had CZS, we observed that live births of self-identified black or mixed race/brown mothers (1.72 (95% CI 1.47 to 2.01) and 1.37 (95% CI 1.24 to 1.51)) were associated with a higher odds of CZS. Live births from single women compared with married women and those from women with less than 12 years of education compared with those with more than 12 years of education also had higher odds of CZS. In addition, live births following fewer prenatal care appointments had increased odds of CZS in the nationwide data. However, in the analyses conducted in the Northeast region (where the microcephaly epidemic started before the link with Zika virus was established and before preventive measures were known or disseminated), no statistical association was found between the number of prenatal care appointments and the odds of CZS. This study shows that live births of the most socially vulnerable women in Brazil had the greatest odds of CZS. This disproportionate distribution of risk places an even greater burden on already socioeconomically disadvantaged groups, and the lifelong disabilities caused by this syndrome may reinforce existing social and health inequalities
Biology · Environmental health · Live birth · Logistic regression · Odds · Odds ratio · Population · Pregnancy · Prenatal care · Public health · Socioeconomic status · Zika virus · Demography · Global Maternal and Child Health · Medicine · Mosquito-borne diseases and control · Nursing · Viral Infections and Vectors · Immunology · Internal Medicine · Pediatrics
Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality
Successes and failures in the control of infectious diseases in Brazil
Socioeconomic risk markers of arthropod-borne virus (arbovirus) infections
Neighbourhood-level income and Zika virus infection during pregnancy in Recife, Pernambuco, Brazil
Barriers in Accessing Care for Consequence of Unsafe Abortion by Black Women
Engagement of Fathers in Parent Group Interventions for Children with Congenital Zika Syndrome
Microcephaly epidemic related to the Zika virus and living conditions in Recife, Northeast Brazil
Diferenciais intra-urbanos de peso ao nascer no município de São Paulo
Systemic And Structural Racism
Epidemia de microcefalia e vírus Zika
Racismo institucional e saúde da população negra
| Citations per year | 2 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |