Insufficient Lycopene Intake Is Associated With High Risk of Prostate Cancer
A Cross-Sectional Study From the National Health and Nutrition Examination Survey (2003–2010)
Bibliographic Data
| ID | 22069798 |
|---|---|
| Authors | You Lyu (0000-0002-6815-6568, Xavier University of Louisiana), You Lu (0000-0002-7524-4179), A D Edwards (0000-0003-4801-7066, Xavier University of Louisiana), Andrea Edwards, Zhong Chen (0009-0007-6692-2648, Xavier University of Louisiana), Tung-Sung Tseng (0000-0001-6266-9891, Louisiana State University Health Sciences Center New Orleans, corresponding author), Mirandy Li (0000-0001-7915-6988, Louisiana State University Health Sciences Center New Orleans), Gabrielle V Gonzalez (0000-0002-8553-4591, Louisiana State University Health Sciences Center New Orleans), Kun Zhang (0000-0003-1636-5373, Xavier University of Louisiana, corresponding author) |
| Year | 2021 |
| Volume | 9 |
| Pages | 792572-792572 |
| Publication date | 2021-12-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2021.792572 |
| PMID | 34966715 |
| OpenAlex | W4200565131 |
| Language | EN |
| Citations received | 2 |
| References cited | 40 |
Although lycopene intake and risk of prostate cancer have been explored for decades, recent studies show that Non-Hispanic Black Prostate Cancer (PCa) patients benefit less than Non-Hispanic White patients from a lycopene intake intervention program. This study examined whether a lycopene intake-related racial disparity exists in reducing the risk of PCa in healthy adults. Data on healthy, cancer-free Non-Hispanic Black (NHB) men ( n = 159) and Non-Hispanic White (NHW) men ( n = 478) from the 2003 to 2010 NHANES dataset were analyzed. Total lycopene intake from daily diet, age, living status, race/ethnicity, education level, poverty income ratio, body mass index, and smoking status were studied as independent variables. The combination of total Prostate-Specific Antigen (PSA) level and the ratio of free PSA was set as criteria for evaluating the risk of PCa. Multivariable logistic regression was used in race-stratified analyses to compute odds ratios (OR) and 95% confidence intervals (95% CI) comparing high PCa risk with low PCa risk. We found, in the whole population, race/ethnicity was the only factor that influenced lycopene intake from the daily diet. NHB men consumed less lycopene than NHW men (3,716 vs. 6,487 (mcg), p = 0.01). Sufficient lycopene intake could reduce the risk of PCa (OR: 0.40, 95% CI: 0.18–0.85, p = 0.02). Men aged between 66 and 70 had high PCa risk (OR: 3.32, 95% CI: 1.12–9.85, p = 0.03). Obesity served as a protective factor against the high risk of PCa (OR: 0.25, 95% CI: 0.12–0.54, p = 0.001). NHW men aged between 66 and 70 had a high risk of PCa (OR: 4.01, 95% CI: 1.02–15.73, p = 0.05). Obese NHW men also had lower risk of PCa (OR: 0.18, 95% CI: 0.07–0.47 p = 0.001). NHB men had a high risk of PCa compared to NHW men (OR: 2.27, 95% CI: 1.35–3.81 p = 0.004). NHB men who were living without partners experienced an even higher risk of PCa (OR: 3.35, 95% CI: 1.01–11.19 p = 0.07). Sufficient lycopene intake from daily food could serve as a protector against PCa. Such an association was only observed in NHW men. Further studies are needed to explore the dose-response relationship between lycopene intake and the association of PCa risk in NHB men
Biology · Body mass index · Cancer · Carotenoid · Confidence interval · Environmental health · Logistic regression · Lycopene · National Health and Nutrition Examination Survey · Obesity · Odds ratio · Population · Prostate cancer · Risk factor · Antioxidant Activity and Oxidative Stress · Cancer, Lipids, and Metabolism · Cholesterol and Lipid Metabolism · Demography · Medicine · Food Science · Internal Medicine
| Citations per year | 0.5 |
|---|---|
| Citation span | 2022 - 2023 (2) |
| Highly cited | No |