Impact of socioeconomic status on cancer staging, survival in non-small cell lung cancer
Bibliographic Data
| ID | 22069999 |
|---|---|
| Authors | Xianghui Yang (0000-0003-3308-3108, Changsha Central Hospital, corresponding author), Liyong Deng (Changsha Central Hospital), Min Li (0000-0002-1163-8961, Changsha Central Hospital), Yongjie Zhou (0009-0002-9772-949X, Fudan University), Guihua Wang (0000-0001-8324-7073, Changsha Central Hospital, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 992944-992944 |
| Publication date | 2022-11-08 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.992944 |
| PMID | 36424960 |
| OpenAlex | W4308592421 |
| Language | EN |
| Citations received | 1 |
| References cited | 41 |
Purpose We performed this study to evaluate the association of socioeconomic status (SES) factors with cancer-specific survival (CSS) of patients with non-small cell lung cancer (NSCLC). We further assessed the predictive value of a novel Tumor Node Metastasis (TNM)-SES staging system, combining the TNM stage with the SES stage. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, we selected 40,378 patients diagnosed with NSCLC from 2012 to 2016. Cox regression method and Harrell's concordance index (C-index) were performed to select the SES factors related to CSS and evaluate the predictive ability of the novel TNM-SES stage. We used Kaplan–Meier curves and a log-rank test to conduct a survival analysis. Results We identified four SES factors (marriage, insurance, education, and household income) associated with CSS and constructed the SES stage (SES-1 and SES-2). NSCLC patients with SES-2 stage (low SES) was associated with young adult, black race, male, squamous carcinoma, upper lobe site, and advanced stage. SES-2 stage patients were significantly associated with a dismal prognosis of patients with NSCLC, with a 21.0% increased risk (HR = 1.21, 95%CI (1.18–1.24), p < 0.001 ). The C-index of our novel TNM-SES stage was 0.732 [95% CI (0.728–0.736)], higher than the traditional TNM stage [0.717, 95% CI (0.715–0.719)], indicating superior predictive value. Conclusion Our population-based study indicated that SES was significantly associated with cancer staging and SCC in patients with NSCLC . Our novel TNM-SES staging system showed a superior predictive value to the traditional TNM stage. The impact of SES on patients with NSCLC should receive more concern in clinical management
Biology · Cancer · Concordance · Lung cancer · Neoplasm staging · Population · Proportional hazards model · Socioeconomic status · TNM staging system · Global Cancer Incidence and Screening · Head and Neck Cancer Studies · Lung Cancer Diagnosis and Treatment · Medicine · Epidemiology · Internal Medicine · Oncology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |