Survival of bronchopulmonary cancers according to radon exposure

Bibliographic Data

ID22087123
AuthorsJuliette Dessemon (0000-0002-5445-8303, Lyon 1 Université, corresponding author), Olivia Pérol (0000-0002-7543-7050, Inserm), Cécile Chauvel (0009-0005-2563-5816, Lyon 1 Université), H Noelle (0000-0002-0743-1714, Lyon 1 Université), Thomas Coudon (0000-0003-0339-3084, Inserm), Lény Grassot (0000-0002-1774-2073, Inserm), Nicolas Foray (0000-0002-1282-1303, Inserm), Élodie Belladame (0000-0002-4381-4624, Inserm), Jérôme Fayette (0000-0002-8126-7019, Centre Léon Bérard), Françoise Fournié (Centre Léon Bérard), Aurélie Swalduz (0000-0002-8398-9373, Centre Léon Bérard), Eve-Marie Neidhart (Centre Léon Bérard), Pierre Saintingy (0000-0002-8090-9323, Centre Léon Bérard), Pierre Saintigny, Mayeul Tabutin (0000-0002-4851-7717, Centre Léon Bérard), Maxime Boussageon (Inserm), Frédéríc Gomez (Centre Léon Bérard), Virginie Avrillon (0000-0002-5508-557X, Centre Léon Bérard), M Pérol (0000-0002-3296-423X, Centre Léon Bérard), Barbara Charbotel (0000-0001-8805-6225, Lyon 1 Université), Beatrice Fervers (0000-0003-3498-6499, Inserm)
Year2024
Volume11
Pages1306455-1306455
Publication date2024-01-24
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1306455
PMID38328545
OpenAlexW4391172644
LanguageEN
Citations received1
References cited36

Introduction: Residential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the second leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives in areas with medium or high radon potential. This study aimed to investigate the impact of radon exposure on the survival of lung cancer patients. Methods: In this single-center study, patients with a histologically confirmed diagnosis of lung cancer, and newly managed, were prospectively included between 2014 and 2020. Univariate and multivariate survival analyses were carried out using a non-proportional risk survival model to consider variations in risk over time. Results: A total of 1,477 patients were included in the analysis. In the multivariate analysis and after adjustment for covariates, radon exposure was not statistically associated with survival of bronchopulmonary cancers (HR = 0.82 [0.54-1.23], HR = 0.92 [0.72-1.18], HR = 0.95 [0.76-1.19] at 1, 3, and 5 years, respectively, for patients residing in category 2 municipalities; HR = 0.87 [0.66-1.16], HR = 0.92 [0.76-1.10], and HR = 0.89 [0.75-1.06] at 1, 3, and 5 years, respectively, for patients residing in category 3 municipalities). Discussion: Although radon exposure is known to increase the risk of lung cancer, in the present study, no significant association was found between radon exposure and survival of bronchopulmonary cancers

Cancer · Environmental health · Lung cancer · Multivariate analysis · Population · Radon · Radon exposure · Survival analysis · Univariate analysis · Effects of Radiation Exposure · Medicine · Radiation Dose and Imaging · Radioactivity and Radon Measurements · Internal Medicine

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