Epidemiological characteristics and risk factors of multidrug-resistant tuberculosis in Luoyang, China

Bibliographic Data

ID22071306
AuthorsZhenzhen Wang (0000-0003-4645-0958, Henan University of Science and Technology), Yi Hou (0000-0001-7778-0322, Luoyang Institute of Science and Technology), Tengfei Guo (0000-0002-6207-7666, First Affiliated Hospital of Henan University of Science and Technology), Tao Jiang (0000-0001-5221-2951, First Affiliated Hospital of Henan University of Science and Technology), Liang Xu (0009-0005-0008-0973, Henan University of Science and Technology), Hongxia Hu (First Affiliated Hospital of Henan University of Science and Technology), Zhanqin Zhao (0000-0002-2593-3945, Henan University of Science and Technology, corresponding author), Yun Xue (0000-0002-4048-5298, Henan University of Science and Technology, corresponding author)
Year2023
Volume11
Pages1117101-1117101
Publication date2023-05-09
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1117101
PMID37228738
OpenAlexW4375950612
LanguageEN
Citations received6
References cited24

Objective We aimed to examine the prevalence of multidrug-resistant tuberculosis (MDR-TB) in Luoyang, China, identify related risk factors, inform clinical practices, and establish standardized anti-tubercular treatment regimens. Methods We conducted a retrospective analysis of high-resolution melting curve (HRM) data from 17,773 cases (2,748 of which were positive) between June 2019 and May 2022 to assess the prevalence of MDR-TB and to identify its associated risk factors. Results Between June 2019 and May 2022, out of the 17,773 HRM results, 2,748 were HRM-positive, and 312 were MDR-TB cases. The detection rates for HRM-positive and MDR-TB were 17.0 and 12.1% for males, and 12.4 and 8.2% for females, respectively. The MDR-TB detection rate was higher in the urban areas (14.6%) than in the rural areas (10.6%) and more common among individuals under 51 years of age (14.1%) than those over 50 years of age (9.3%). Notably, the rate of detecting MDR-TB was 18.3% higher in new male patients than in new female patients, which was at 10.6%, and this difference was statistically significant ( p < 0.001). Moreover, the rate of MDR detection in females who had received anti-tuberculosis treatment (21.3%) was higher than that in males (16.9%). In the multivariate model that considered the results of the sputum smear and detection time, MDR-TB was positively correlated with a history of tuberculosis (TB) treatment, being male, being younger than 51 years, and living in urban areas. Conclusion Local TB infections are complex and diverse; therefore, more comprehensive monitoring methods are needed to curb the spread of MDR-TB

Biology · Drug resistance · Multi-drug-resistant tuberculosis · Multiple drug resistance · Multivariate analysis · Mycobacterium tuberculosis · Pathology · Retrospective cohort study · Sputum · Tuberculosis · Diagnosis and treatment of tuberculosis · Malaria Research and Control · Medicine · Tuberculosis Research and Epidemiology · Epidemiology · Internal Medicine

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