Quantitative Sars-CoV-2 Antibody Screening of Healthcare Workers in the Southern Part of Kyoto City During the Covid-19 Pre-pandemic Period
Bibliographic Data
| ID | 22072832 |
|---|---|
| Authors | Kentaro Fujita (0000-0002-6902-9085, Kyoto Medical Center, corresponding author), Kohei Fujita (0000-0002-4292-6819), Shinpei Kada (0000-0002-3296-2736, Kyoto Medical Center), Osamu Kanai (0000-0003-0736-3317, Kyoto Medical Center), Hiroaki Hata (0000-0002-8902-0256, Kyoto Medical Center), Takao Odagaki (Kyoto Medical Center), Noriko Satoh-Asahara, Noriko Satoh‐Asahara (0000-0002-8645-3144, Kyoto Medical Center), Tetsuya Tagami (0000-0001-6266-3027, Kyoto Medical Center), Akihiro Yasoda (0000-0001-8866-5303, Kyoto Medical Center) |
| Year | 2020 |
| Volume | 8 |
| Pages | 595348-595348 |
| Publication date | 2020-12-07 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2020.595348 |
| PMID | 33365297 |
| OpenAlex | W3110665168 |
| Language | EN |
| Citations received | 2 |
| References cited | 15 |
Background: The coronavirus disease-2019 (COVID-19) pandemic is associated with a heavy burden on the mental and physical health of patients, regional healthcare resources, and global economic activity. While understanding of the incidence and case-fatality rates has increased, there are limited data concerning seroprevalence of antibodies against the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in healthcare workers during the pre-pandemic period. This study aimed to quantitatively evaluate seroprevalence of SARS-CoV-2 antibodies in healthcare workers in the southern part of Kyoto city, Japan. Methods: We prospectively recruited healthcare workers from a single hospital between April 10 and April 20, 2020. We collected serum samples from these participants and quantitatively evaluated SARS-CoV-2 IgG antibody levels using enzyme-linked immunosorbent assays. Results: Five (5.4%), 15 (16.3%), and 72 (78.3%) participants showed positive, borderline, and negative serum SARS-CoV-2 IgG antibody status, respectively. We found the mean titer associated with each antibody status (overall, positive, borderline, and negative) was clearly differentiated. Participants working at the otolaryngology department and/or with a history of seasonal common cold symptoms had a significantly higher SARS-CoV-2 IgG antibody titer ( p = 0.046, p = 0.046, respectively). Conclusions: Five (5.4%) and 15 (16.3%) participants tested positive and borderline, respectively, for SARS-CoV-2 IgG antibody during the COVID-19 pre-pandemic period. These rates were higher than expected, based on government situation reports. These findings suggest that COVID-19 had already spread within the southern part of Kyoto city at the early stage of the pandemic
Antibody · Antibody titer · Case fatality rate · Disease · Health care · Pandemic · Serology · Seroprevalence · Titer · COVID-19 Clinical Research Studies · Long-Term Effects of COVID-19 · Medicine · SARS-CoV-2 and COVID-19 Research · Emergency Medicine · Epidemiology · Immunology · Internal Medicine · Virology
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China
Clinical Characteristics of Coronavirus Disease 2019 in China
Quantitative Sars-CoV-2 Antibody Screening of Healthcare Workers in the Southern Part of Kyoto City During the Covid-19 Pre-pandemic Period
| Citations per year | 0.33 |
|---|---|
| Citation span | 2020 - 2021 (2) |
| Highly cited | No |