A first insight into tuberculosis transmission at the border of Ecuador and Colombia

A retrospective study of the population structure of Mycobacterium tuberculosis in Esmeraldas province

Bibliographic Data

ID22072931
AuthorsBernardo Castro-Rodriguez (0000-0002-5943-1580, Universidad de Las Américas), Sebastián Espinoza-Andrade (Universidad de Las Américas), Greta Franco-Sotomayor (0000-0002-3068-2546, Universidad Católica de Santiago de Guayaquil), José Manuel Benítez-Medina (Universidad de Extremadura), Natalia Jiménez-Pizarro (0000-0002-8051-5738, Universidad de Extremadura), Camilo Cárdenas-Franco, Camilo S Cardenas-Franco (Universidad Católica de Santiago de Guayaquil), Juan C Granda (0000-0001-8214-6019, Instituto Nacional de Investigación en Salud Pública), Jose Luis Jouvin (Universidad Católica de Santiago de Guayaquil), Solon Alberto Orlando-Narváez (0000-0002-5787-3115, Universidad de Especialidades Espíritu Santo), Solon Alberto Orlando, J Hermoso de Mendoza (0000-0002-5574-4432, Universidad de Extremadura), Miguel Ángel García-Bereguiain (0000-0003-0025-3609, Universidad de Las Américas, corresponding author)
Year2024
Volume12
Pages1343350-1343350
Publication date2024-02-07
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1343350
PMID38384875
OpenAlexW4391610037
LanguageEN
Citations received2
References cited30

Objective: complex (MTBC) and to identify active transmission clusters of regional importance. Methods: We studied the potential transmission of TB between Colombia and Ecuador through the analysis of the population structure of MTBC lineages circulating in the Ecuadorian province of Esmeraldas at the border with Colombia. A total of 105 MTBC strains were characterized by 24-loci MIRU-VNTR and spoligotyping. Results: MTBC lineage 4 is only present in Esmeraldas; no MTBC strains belonging to Lineage 2-sublineage Beijing were found despite its presence in other provinces of Ecuador and, in Colombia. Genotyping results revealed a high degree of diversity for MTBC in Esmeraldas: Neither active transmission clusters within this province nor including MTBC strains from Colombia or other provinces of Ecuador were found. Conclusion: Our data suggest that tuberculosis dynamics in this rural and isolated area may be not related to highly transmitted strains but could be influenced by other health determinants that favor TB relapse such as poverty and poor health system access. Further studies including a larger number of MTBC strains from Esmeraldas are necessary to test this hypothesis

Biology · Environmental health · Genotype · Genotyping · Molecular epidemiology · Mycobacterium tuberculosis · Mycobacterium tuberculosis complex · Pathology · Population · Tuberculosis · Diagnosis and treatment of tuberculosis · Medicine · Pneumocystis jirovecii pneumonia detection and treatment · Tuberculosis Research and Epidemiology · Epidemiology · Genetics · Virology

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