Depiction of Vaginal Microbiota in Women With High-Risk Human Papillomavirus Infection
Bibliographic Data
| ID | 22075751 |
|---|---|
| Authors | Zhen-Tong Wei, Zhentong Wei (Jilin University), Hongliang Chen (0000-0003-0141-1074, Jilin Agricultural University), Hong-Liang Chen, Chunfeng Wang (0000-0001-9949-7528, Jilin Agricultural University), Chun-Feng Wang, Guilian Yang (0000-0001-5224-1592, Jilin Agricultural University), Gui-Lian Yang, Shumei Han (0009-0007-6741-5322, Jilin University, corresponding author), Shu-Mei Han, Song-Ling Zhang (Jilin University, corresponding author) |
| Year | 2021 |
| Volume | 8 |
| Pages | 587298-587298 |
| Publication date | 2021-01-08 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2020.587298 |
| PMID | 33490017 |
| OpenAlex | W3120124770 |
| Language | EN |
| Citations received | 1 |
| References cited | 50 |
Persistent infection with the carcinogenic human papillomavirus (HPV) is a prerequisite for the progression of cervical lesions and cancer. A growing body of research has focused on the functional role of the vaginal microbiota in the persistence of HPV infection. Understanding the microbial composition and structure in women with high-risk (hr)-HPV infection may help reveal associations between the vaginal microbiota and HPV infection, and identify potential biomarkers. Our study investigated the vaginal microbial community in women with and without hr-HPV infection, by using 16s rRNA gene sequencing. We found that microbial perturbations occurred in the early phase of hr-HPV infection. Lactobacillus and Sporolactobacillus were decreased, while bacteria related to bacterial vaginosis (BV), such as Gardnerella, Prevotella, Dialister, Slackia, Actinomyces, Porphyromonas, Peptoniphilus, Anaerococcus, Peptostreptococcus, Streptococcus, Ureaplasma, Megasphaera , and Mycoplasma were increased. Our results could offer insights into the correlations between hr-HPV and the vaginal microbiota in the early infection period, and provide indications that the predominance of some BV-associated bacteria during hr-HPV infection may increase the risk for cervical neoplasia
Actinomyces · Bacteria · Bacterial vaginosis · Bioinformatics · Biology · Cancer · Cervical cancer · Chlamydia · Chlamydia trachomatis · Gardnerella vaginalis · HPV infection · Microbiome · Mycoplasma · Mycoplasma genitalium · Prevotella · Ureaplasma · Vaginal flora · Cervical Cancer and HPV Research · Gut microbiota and health · Medicine · Reproductive tract infections research · Genetics · Immunology · Internal Medicine · Microbiology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |