Association Between Depression and Risk of Incident Cardiovascular Diseases and Its Sex and Age Modifications
A Prospective Cohort Study in Southwest China
Bibliographic Data
| ID | 22075928 |
|---|---|
| Authors | Lisha Yu (0000-0002-1388-7187), Yun Chen (0000-0001-5123-1624, Fudan University), Na Wang (0000-0003-1102-8220, Fudan University), Kelin Xu (0000-0002-6788-4256, Fudan University), Chenghan Wu, Cheng-Han Wu (0000-0003-4399-0772, Guizhou Center for Disease Control and Prevention), Tao Liu (0000-0001-5480-2568, Guizhou Center for Disease Control and Prevention, corresponding author), Chaowei Fu (0000-0003-0966-8552, Fudan University, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 765183-765183 |
| Publication date | 2022-03-30 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.765183 |
| PMID | 35433580 |
| OpenAlex | W4221051713 |
| Language | EN |
| Citations received | 1 |
| References cited | 31 |
To examine possible associations between depression and cardiovascular disease (CVD) incidence and whether demographic factors modified those associations in the Chinese population. This prospective cohort study comprised 7,735 adults aged 18 years or older in Guizhou, China from 2010 to 2020. The Patient Health Questionnaire-9 (PHQ-9) was used to measure the prevalence of depression. Cox proportional hazard models were used to estimated hazard ratios (HRs) and 95% confidence intervals (95%CIs) of depression and incident CVD. We identified 215 CVD cases (including 28 acute myocardial infarction (AMI) and 197 stroke cases) during an average follow-up of 7.07 years. In the multivariable-adjusted model, baseline PHQ-9 score was associated with incident CVD, AMI, and stroke. The HR per 1-SD increase for PHQ-9 score was 1.14 (95%CI: 1.03, 1.26) for CVD, 1.26 (95%CI: 1.01, 1.57) for AMI, and 1.12 (95%CI: 1.01, 1.25) for stroke. Compared with participants without depression, those with any mild or more advanced depression had a higher risk of incident CVD (HR: 1.69, 95%CI: 1.08, 2.64) and AMI (HR: 3.36, 95%CI: 1.17, 10.56). Associations between depression with CVD and stroke were suggested to be even stronger among women and participants aged <65 years ( P for interaction <0.05). The effect of depression on stroke tended to be preserved in non-smokers. Depression was associated with a higher risk of incident CVD, AMI, and stroke in adults of Southwest, China, particularly in women, participants aged <65 years, and non-smokers. These findings highlighted the importance and urgency of depression healthcare
Cohort · Cohort study · Confidence interval · Depressive symptoms · Diabetes mellitus · Environmental health · Hazard ratio · Myocardial infarction · Patient Health Questionnaire · Population · Proportional hazards model · Prospective cohort study · Cardiac Health and Mental Health · Employment and Welfare Studies · Health disparities and outcomes · Medicine · Endocrinology · Internal Medicine
Standardization of the depression screener Patient Health Questionnaire (PHQ-9) in the general population
Classification and Diagnosis of Diabetes
Depression and the Dynamics of Smoking
Overweight, Obesity, and Depression
Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general population
Associations of Depression With C-Reactive Protein, IL-1, and IL-6
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |