Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China
A Population-Based Case-Control Study
Bibliographic Data
| ID | 22076281 |
|---|---|
| Authors | Li-Li Li (0000-0002-8810-7747), Lili Li (0000-0002-9793-3995, Shenyang 242 Hospital), Yan-Hong Huang, Yan‐Hong Huang (0000-0003-2014-7117, Shenyang First People's Hospital), Jing Li (0000-0001-7792-4322, Shenyang 242 Hospital), Shu Liu (0000-0001-8312-0080, Beijing Municipal Ecological and Environmental Monitoring Center), Yanling Chen (0000-0002-6387-8561), Yan-Ling Chen, Chengzhi Jiang (0009-0006-9340-5091, Shenyang Ligong University), Cheng-Zhi Jiang, Zong-Jiao Chen, Zong‐Jiao Chen (Beijing Municipal Ecological and Environmental Monitoring Center), Yanyan Zhuang (0000-0002-8407-0801, China Medical University, corresponding author), Yan-Yan Zhuang |
| Year | 2022 |
| Volume | 10 |
| Pages | 821905-821905 |
| Publication date | 2022-05-12 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.821905 |
| PMID | 35646802 |
| OpenAlex | W4280564303 |
| Language | EN |
| References cited | 37 |
Evidence of the association between maternal sulfur dioxide (SO 2 ) exposure and the risk of omphalocele is limited and equivocal. We aimed to assess the aforementioned topic during the first trimester of pregnancy. A population-based case-control study was carried out in infants consisting of 292 cases of omphalocele and 7,950 healthy infant controls. Exposure to SO 2 , particulate matter with aerodynamic diameters ≤ 10 μm, and nitrogen dioxide was assessed by averaging the concentration from all stations in the mother's residential city. SO 2 exposure was categorized into three groups, with the lowest tertile defined as the reference category. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression models. Higher SO 2 exposure during the first trimester was significantly associated with omphalocele risk [per standard deviation (42 ug/m 3 ) increment: OR = 1.39, 95% CI = 1.22–1.65]. When focusing on shorter exposure windows, similar positive associations were observed for SO 2 exposure in the first and third months of pregnancy. In addition, compared with the lowest tertile, high SO 2 exposure in the second month of pregnancy increased the risk of omphalocele (OR = 2.80, 95% CI = 1.61–4.97). Maternal exposure to SO 2 during the first trimester may increase the risk of omphalocele in offspring
Biology · China · Chinese population · Environmental health · Geography · Omphalocele · Population · Pregnancy · Sulfur dioxide · Climate Change, Adaptation, Migration · Congenital Anomalies and Fetal Surgery · Environmental Science · Medicine · Urological Disorders and Treatments · Ecology
| Citation velocity | historical |
|---|---|
| Highly cited | No |