A real-world, cross-sectional, and longitudinal study on high-risk human papillomavirus genotype distribution in 31,942 women in Dongguan, China
Bibliographic Data
| ID | 22076819 |
|---|---|
| Authors | Huanxia Zhong (Dongguan People’s Hospital), Wenwei Pan (Dongguan People’s Hospital), Binbin Chen (0000-0001-5962-3147, BGI Group (China)), Jiamin Gu (0000-0001-6231-0619, Dongguan People’s Hospital), Liang Yu (0000-0002-4597-885X, Dongguan People’s Hospital), Yu Liang (0009-0002-8666-8046), Guoli Sun (0000-0001-8888-379X, Dongguan People’s Hospital), Xinghua Huang (0000-0003-3049-100X, Dongguan People’s Hospital), Huitao Yuan (Dongguan People’s Hospital), Haina Guo, H N Guo (0000-0003-4386-7854, Dongguan People’s Hospital), Ling Zhong (0000-0002-0196-4587, Dongguan People’s Hospital), Zhuanfen Li (Dongguan People’s Hospital), Ping Zhou (0000-0003-1974-4424, Dongguan People’s Hospital, corresponding author), Zhou Ping (0000-0001-5471-5261), Siliang Zeng (0009-0002-5863-8659, Dongguan People’s Hospital, corresponding author), Li Tang (0000-0001-8311-2507, Dongguan People’s Hospital, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1409030-1409030 |
| Publication date | 2024-08-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1409030 |
| PMID | 39148652 |
| OpenAlex | W4401218280 |
| Language | EN |
| References cited | 27 |
Background Persistent human papillomavirus (HPV) infection remains a key risk factor for cervical cancer. HPV-based primary screening is widely recommended in clinical guidelines, and further longitudinal studies are needed to optimize strategies for detecting high-grade cervical lesions compared to cytology. Methods From November 2015 to December 2023, 31,942 participants were included in the real-world observational study. Among those, 4,219 participants underwent at least two rounds of HPV tests, and 397 completed three rounds of HPV tests. All participants were tested for high-risk types of HPV 16/18/31/33/35/39/45/51/52/56/58/59/66/68 (hrHPV) and low-risk types of HPV6/11 genotyping. Some participants also received cytology or colposcopy with pathology. Results In the cross-sectional cohort, the prevalence of hrHPV and all HPV subtypes was 6.6% (2,108/31,942) and 6.8% (2,177/31,942), respectively. The three top hrHPV genotypes were HPV52 (1.9%), HPV58 (0.9%), and HPV16 (0.9%). Age distributions showed two peaks at 45–49 and 60–65 years. For the primary screening cohort, the hrHPV prevalence rate increased from 4.8% in 2015–2017 to 7.0% in 2020–2020 and finally reached 7.2% in 2023. For the longitudinal cohort study, the hrHPV prevalence rates in the repeated population (3.9, 5.3, and 6.0%) were lower than the primary hrHPV screening rates (6.6%), which indicated that repeated screening might decrease the prevalence rate. Methodologically, the hrHPV (89.5%) and the screening group of 16 subtypes (92.3%) demonstrated superior sensitivity than the cytology group (54.4%). Moreover, the longitudinal study indicated that the persistent hrHPV subgroup had a significantly higher ( p = 0.04) incidence of high-grade squamous intraepithelial lesions and more histology progression events (7/17 vs. 0/5) than the reinfection group. Conclusion The study indicates a rising high-risk HPV prevalence in Dongguan, with repeated screening reducing this trend. The findings support HPV-based primary screening and might guide HPV vaccination and cervical cancer prevention in South China
Biology · China · Cross-sectional study · Environmental health · Gene · Genotype · Geography · Human papillomavirus · Pathology · Sociology · Cervical Cancer and HPV Research · Demography · Head and Neck Cancer Studies · Mathematics · Medicine · Reproductive tract infections research · Genetics · Internal Medicine · Virology
| Highly cited | No |
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