Study on the 1990–2021 trend of global childhood respiratory infection and tuberculosis disease burden and related risk factors
Bibliographic Data
| ID | 22077117 |
|---|---|
| Authors | Jie Chen (0000-0002-9254-4413, Hengyang Normal University), Chao Fang (0000-0002-7072-6072, Hengyang Normal University, corresponding author), Weihong Lu (0000-0002-1051-4043, First Affiliated Hospital of Xinxiang Medical University), Xiangtao Wu (0000-0002-2277-9612, First Affiliated Hospital of Xinxiang Medical University), Xingliang Zhang (0000-0003-1103-2799), Xinliang Zhang (0000-0001-8513-3328, Shenzhen Children's Hospital) |
| Year | 2025 |
| Volume | 13 |
| Pages | 1609990-1609990 |
| Publication date | 2025-07-30 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2025.1609990 |
| PMID | 40809749 |
| OpenAlex | W4412764843 |
| Language | EN |
| References cited | 21 |
Background: Respiratory tract infections (RTIs) and tuberculosis (TB) impose a critical global health burden on children, serving as leading causes of morbidity and mortality. Lower respiratory tract infections (LRIs) remain the primary cause of death in under-5 s, though mortality has declined recently. Objective: This study aims to analyze trends in RTIs and TB among 0-14-year-olds using Global Burden of Disease (GBD) data from 1990 to 2021. Methods: Global data on childhood RTIs and TB were collected from GBD, with standardized methods used to assess disease burden trends, age/sex/SDI differences, and the contribution of 11 risk factors. Results: From 1990 to 2021, incidences of upper RTIs, otitis media, and TB decreased, but overall RTIs increased. Neonatal LRI had the highest mortality (1,560.6/100 k). Male children showed higher TB incidence/mortality. Low-SDI areas had the highest burden (mortality 2.036/100 k), while high-SDI areas saw the largest TB mortality drop (95.7%). Underweight remained the main risk factor, with DALY rate falling 80.3%, though household air pollution, low birth weight, short gestation, and high temperature rose in rank. Conclusion: Global childhood respiratory disease burden faces challenges, requiring strengthened international cooperation and targeted interventions, especially in low-SDI regions, to improve public health and nutrition
Body mass index · Burden of disease · Disease · Disease burden · Environmental health · Global health · Otitis · Overweight · Population · Public health · Respiratory system · Respiratory tract infections · Tuberculosis · Underweight · Medicine · Pneumonia and Respiratory Infections · Respiratory viral infections research · Tuberculosis Research and Epidemiology · Internal Medicine · Pediatrics · Surgery
Revisiting maternal and child undernutrition in low-income and middle-income countries
Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016
Respiratory risks from household air pollution in low and middle income countries
What are the risk factors for death among children with pneumonia in low- and middle-income countries? A systematic review
Global, regional, and national burden of tuberculosis and attributable risk factors for 204 countries and territories, 1990–2021
| Citation velocity | historical |
|---|---|
| Highly cited | No |