The phenotype of type 1 diabetes in sub-Saharan Africa
Bibliographic Data
| ID | 22077873 |
|---|---|
| Authors | Jean-Claude Katte (0000-0001-5631-2810, University of Exeter, corresponding author), Jean Claude Katte, Terrence J Mcdonald (0000-0003-3559-6660, University of Exeter), Timothy J McDonald, Eugène Sobngwi (0000-0001-5457-6572, Université de Yaoundé I), Angus Jones (0000-0002-0883-7599, University of Exeter), Angus G Jones |
| Year | 2023 |
| Volume | 11 |
| Pages | 1014626-1014626 |
| Publication date | 2023-01-27 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2023.1014626 |
| PMID | 36778553 |
| OpenAlex | W4318294159 |
| Language | EN |
| Citations received | 2 |
| References cited | 118 |
The phenotype of type 1 diabetes in Africa, especially sub-Saharan Africa, is poorly understood. Most previously conducted studies have suggested that type 1 diabetes may have a different phenotype from the classical form of the disease described in western literature. Making an accurate diagnosis of type 1 diabetes in Africa is challenging, given the predominance of atypical diabetes forms and limited resources. The peak age of onset of type 1 diabetes in sub-Saharan Africa seems to occur after 18–20 years. Multiple studies have reported lower rates of islet autoantibodies ranging from 20 to 60% amongst people with type 1 diabetes in African populations, lower than that reported in other populations. Some studies have reported much higher levels of retained endogenous insulin secretion than in type 1 diabetes elsewhere, with lower rates of type 1 diabetes genetic susceptibility and HLA haplotypes. The HLA DR3 appears to be the most predominant HLA haplotype amongst people with type 1 diabetes in sub-Saharan Africa than the HLA DR4 haplotype. Some type 1 diabetes studies in sub-Saharan Africa have been limited by small sample sizes and diverse methods employed. Robust studies close to diabetes onset are sparse. Large prospective studies with well-standardized methodologies in people at or close to diabetes diagnosis in different population groups will be paramount to provide further insight into the phenotype of type 1 diabetes in sub-Saharan Africa
Allele · Antigen · Biology · Diabetes mellitus · Disease · Environmental health · Gene · Haplotype · Human leukocyte antigen · Population · Type 1 diabetes · Type 2 diabetes · Diabetes and associated disorders · Diabetes Management and Research · Medicine · Pancreatic function and diabetes · Endocrinology · Genetics · Immunology · Internal Medicine
| Unique citing works | 2 |
|---|---|
| Citations per year | 1 |
| Citation span | 2024 - 2026 (3) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 2 |