A cross-sectional study of seroprevalence in Armenia, 2025
Measles, mumps, rubella, and diphtheria
Bibliographic Data
Introduction Prevention and control of vaccine-preventable infections is a key component of maintaining public health, and the overall state of immunity is the determining factor. Objective of the study To study herd immunity of the Armenian population to measles, rubella, mumps, and diphtheria. Materials and methods The study involved 5,513 individuals from all regions aged from 1 year and above. A cohort of volunteers, stratified into 9 age groups, was formed including by region and activity using a web application. For each infection, the presence and/or levels of immunoglobulin G were determined by the enzyme immunoassay method using Russian-made test systems. Results The cohort average seroprevalence values for measles, rubella, mumps, and diphtheria were 88.3%, 97.2, 83.2, and 56.3%, respectively. The least protected age groups were: children 200 IU/mL); and a basic protective level of diphtheria toxin Abs (0.1–1 IU/mL). With age, a trend is seen: seropositivity for the viral pathogens (measles, mumps, and rubella) increased to maximum values; and diphtheria seropositivity decreased to minimum values. Conclusion The level of herd immunity in Armenia is sufficient only for rubella, as confirmed by the absence of cases. Currently, immunity to measles and mumps is present, which prevents outbreaks but may not be fully preventive of sporadic cases. Despite the absence of diphtheria, insufficient protection in older adults makes them a risk group for incidence and severity. However, immunity levels in our study were assessed based only on humoral immunity, which may underrepresent the full immunological response, including that mediated by cellular immunity
Diphtheria · Herd immunity · Immunity · Measles · Outbreak · Population · Rubella · Seroprevalence · Immune responses and vaccinations · Vaccine Coverage and Hesitancy · Virology and Viral Diseases
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