Joint exposure to PM2.5, warm-season heat, and sedentary behavior accelerates incident lung cancer in ageing Chinese adults
Evidence from CHARLS
Bibliographic Data
| ID | 22079646 |
|---|---|
| Authors | Yang-Zhong Wang, Yangzhong Wang (0000-0001-8281-0995, Fuling Center Hospital of Chongqing), Nan Tang (0000-0001-9702-8402, Fuling Center Hospital of Chongqing), Tao Tao (0000-0001-9865-5985, Fuling Center Hospital of Chongqing), Xian-Lin Peng (Fuling Center Hospital of Chongqing, corresponding author) |
| Year | 2025 |
| Volume | 13 |
| Pages | 1622767-1622767 |
| Publication date | 2025-07-08 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2025.1622767 |
| PMID | 40697836 |
| OpenAlex | W4412618700 |
| Language | EN |
| References cited | 54 |
Objective: Joint exposure to fine particulate matter (PM2.5) and prolonged sedentary behavior in later life may erode physiological reserve and hasten carcinogenesis, yet evidence quantifying their combined impact on incident lung cancer among older Chinese adults is sparse. We investigated whether co-occurrence of high ambient PM2.5 and extensive sitting time accelerates incident lung cancer in a nationally representative cohort. Methods: . Eight joint-exposure categories crossed environmental burden (low/low, high PM2.5 only, high heat only, high/high) with sedentary status (low vs. high). Weighted Cox models with age as the time axis estimated hazard ratios (HRs) for incident lung cancer; additive interaction was assessed via relative excess risk due to interaction (RERI) and synergy index (S). Results: Over 43,181 person-years, 141 incident lung-cancer cases were recorded (3.3 per 1,000 person-years). Independently, high PM2.5 (HR 1.82, 95% CI 1.29-2.57) and high sedentary time (HR 2.10, 95% CI 1.55-2.84) increased risk. Participants simultaneously exposed to high PM2.5, high warm-season heat, and ≥8 h sitting exhibited a nearly five-fold hazard (HR 4.95, 95% CI 2.24-10.95) versus the dual-low reference. Additive interaction was evident (RERI 1.10, synergy index 1.39), and associations were most pronounced in men and rural residents. Sensitivity analyses varying sedentary thresholds, excluding early events, and applying competing-risk models yielded consistent findings. Conclusion: Concurrent high ambient PM2.5 and prolonged sedentary behavior markedly accelerate incident lung cancer in middle-aged and older Chinese adults, with evidence of biologic synergy beyond independent effects. Integrated interventions that couple aggressive air-quality regulation with strategies to curtail sedentary time-particularly among socio-economically disadvantaged and rural populations-are warranted to mitigate China's looming lung-cancer burden in an aging society
Environmental health · Air Quality and Health Impacts · Computer Science · Engineering · Health, Environment, Cognitive Aging · Medicine · Physical Activity and Health
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National and provincial burden of disease attributable to fine particulate matter air pollution in China, 1990–2021
| Citation velocity | historical |
|---|---|
| Highly cited | No |