Association Between Abca1 Gene Polymorphisms and the Risk of Hypertension in the Chinese Han Population
Bibliographic Data
| ID | 22085566 |
|---|---|
| Authors | Yan-Li Ren (0009-0003-8464-6254, Hangzhou Normal University), Yanli Ren (Hangzhou Normal University), Enyu Tong (Hangzhou Normal University), Chunhong Di (0000-0002-6837-3730, Affiliated Hospital of Hangzhou Normal University), Yunheng Zhang (Hangzhou Normal University), Liangwen Xu (0000-0002-8410-2965, Hangzhou Normal University), Xiaohua Tan (0000-0003-1577-2786, Hangzhou Normal University, corresponding author), Lei Yang (0000-0002-8956-6478, Hangzhou Normal University, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 878610-878610 |
| Publication date | 2022-05-20 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.878610 |
| PMID | 35669754 |
| OpenAlex | W4280562667 |
| Language | EN |
| References cited | 41 |
Background: Hypertension is rising as a major public health burden around the world. This study explored the association between single-nucleotide polymorphisms (SNPs) in the adenosine triphosphate (ATP)-Binding Cassette Subfamily A1 (ABCA1) gene and hypertension among Chinese Han adults. Method: A total of 2,296 Han Chinese in southeast China were recruited for this study. We collected medical reports, lifestyle details, and blood samples from individuals. The polymerase chain reaction-ligase detection reaction (PCR-LDR) method was used to detect the genotypes of these SNPs in the ABCA1 gene. Results: After adjusting some covariates, the additive and recessive models of the rs2472510 and rs2515614 were significantly associated with hypertension. The haplotypes TCTA (rs2297406-rs2472433-rs2472510-rs2515614) were associated with high SBP, and the haplotypes CCTA, TCTA, and TTTA were associated with high diastolic blood pressure (DBP). Conclusion: The results of the relationship between the polymorphisms of rs2297406, rs2472433, rs2472510, and rs2515614 in ABCA1 and hypertension in southeastern China would provide a theoretical basis for genetic screening and disease prevention
ABCA1 · Bioinformatics · Biology · Blood pressure · China · Chinese people · Gene · Genotype · Haplotype · Polymerase chain reaction · Single-nucleotide polymorphism · Cholesterol and Lipid Metabolism · Medicine · Peroxisome Proliferator-Activated Receptors · Renin-Angiotensin System Studies · Genetics · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |