Pertussis resurgence and epidemiology of fully vaccinated cases in eastern China
Evidence for vaccination timing
Bibliographic Data
| ID | 22086848 |
|---|---|
| Authors | Kai Gao (0000-0003-2571-7967, Zhejiang Center for Disease Control and Prevention), Yao Zhu (0000-0002-8518-0279, Zhejiang Center for Disease Control and Prevention), Yang Zhou (0000-0002-4537-9857, Zhejiang Center for Disease Control and Prevention), Linling Ding (Zhejiang Center for Disease Control and Prevention), Hui Liang (0000-0003-1341-6980, Zhejiang Center for Disease Control and Prevention), Hanqing He (0000-0003-0863-5177, Hangzhou Center for Disease Control and Prevention), Xiaohua Qi (Hangzhou Center for Disease Control and Prevention, corresponding author) |
| Year | 2025 |
| Volume | 13 |
| Pages | 1677699-1677699 |
| Publication date | 2025-10-07 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2025.1677699 |
| PMID | 41127599 |
| OpenAlex | W4414877570 |
| Language | EN |
| References cited | 33 |
Objectives: This study aimed to comprehensively analyze the epidemiology of pertussis based on case characteristics and vaccination history in Zhejiang Province. Methods: We analyzed clinically diagnosed and laboratory-confirmed pertussis cases (aged 0-18 years old) reported in Zhejiang Province from January 2016 to December 2024. Vaccination history data were matched from the Zhejiang Provincial Immunization Information System. Results: A total of 63,664 pertussis cases were identified in Zhejiang Province, China. The annual incidence of pertussis among individuals aged 0-18 years increased gradually from 2016 (1.46/100,000) to 2023 (14.22/100,000), followed by a drastic surge to 512.56/100,000 in 2024. During the resurgence, incidence rose most substantially in kindergarten (3-6 years) and lower elementary (7-9 years) children, surpassing the incidence of infants in 2024. Among 55,968 identified pertussis cases with data on vaccination status, the proportion of fully vaccinated cases increased from 12.50% in 2016 to 79.24% in 2024. Among 43,004 fully vaccinated cases, kindergarten children accounted for the highest proportion (51.27%), followed by the lower elementary children (34.58%). Regarding infection timing, 68.4% of fully vaccinated cases occurred after 6 years old, whereas 31.6% occurred before 6. The median interval between last vaccine dose and disease onset was 61.45 months (interquartile range: 48.15-79.47 months). Conclusion: Our findings underscore the critical need for booster vaccination at 4-6 years, and highlight the necessity for future research to focus on vaccine safety, effectiveness, and cost-effectiveness in optimizing vaccination strategies
Booster dose · MEDLINE · Pertussis vaccine · Vaccination · Whooping cough · Bacterial Infections and Vaccines · Pneumonia and Respiratory Infections · Vaccine Coverage and Hesitancy · Epidemiology
| Highly cited | No |
|---|