Association between single and multiple cardiometabolic diseases and depression

A cross-sectional study of 391,083 participants from the UK biobank

Bibliographic Data

ID22087286
AuthorsLi Gong (0000-0001-7135-009X, Central South University), Tianqi Ma (0000-0002-2919-4764, Central South University), Lingfang He (Central South University), Guoqiang Lin, Guo‐Qiang Lin (0000-0002-8209-5263, Central South University), Guogang Zhang (0000-0002-8678-2167, Central South University), Xunjie Cheng (0000-0001-8766-0594, Central South University, corresponding author), Fanyan Luo (0000-0002-1195-4585, Central South University, corresponding author), Yongping Bai (0000-0002-7316-6066, Central South University, corresponding author)
Year2022
Volume10
Pages904876-904876
Publication date2022-08-04
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2022.904876
PMID35991068
OpenAlexW4289838550
LanguageEN
Citations received3
References cited40

Background: Individual cardiometabolic diseases (CMDs) are associated with an increased risk of depression, but it's unclear whether having more than one CMD is associated with accumulative effects on depression. We aimed to assess the associations between CMDs and depression and determine the accumulative extent. Methods: In this cross-sectional study based on UK Biobank, participants with available information on CMDs and depression were enrolled. The history of CMDs was derived from self-reported medical history and electrical health-related records. Depression status was assessed by the aggregation of self-reported history and antidepressant use, depression (Smith), and hospital inpatient diagnoses. Logistic regression models were fitted to assess the association between the number or specific patterns of CMDs and depression and to test the accumulative effect of CMD number, adjusting for confounding factors. Results: < 0.001). In the full-adjusted model, participants with one [odds ratio (OR) 1.26, 95% confidence interval (CI) 1.23-1.29], two (OR 1.50, 95% CI 1.44-1.56), and three or more (OR 2.13, 95% CI 1.97-2.30) CMD(s) had an increased risk of depression. A significant, accumulative dose-related relationship between the number of CMDs and depression was observed (OR 1.25, 95% CI 1.24-1.27). The dose-dependent accumulative relationship was consistent in stratified analyses and sensitivity analyses. Conclusions: CMDs were associated with a higher risk of depression, and there was an accumulative relationship between CMD number and depression

Biobank · Bioinformatics · Comorbidity · Confidence interval · Confounding · Cross-sectional study · Logistic regression · Odds ratio · Cardiac Health and Mental Health · Cardiovascular Health and Risk Factors · Demography · Heart rate and cardiovascular health · Medicine · Internal Medicine

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