Improving physical and mental health in women with breast cancer undergoing anthracycline-based chemotherapy through wearable device-based aerobic exercise

A randomized controlled trial

Bibliographic Data

ID22089900
AuthorsHongmei Li (0009-0008-0342-8295, Minzu University of China), Die Sang (0009-0001-9637-4220, Cancer Hospital of Huanxing Chaoyang District Beijing), Lijing Gong (0000-0003-3502-0901, Beijing Sport University), Boliang Wang (0000-0003-0323-637X, The University of Sydney), Yong Wang (0000-0002-0092-0793, Chinese Academy of Medical Sciences & Peking Union Medical College), Xiao Jia (0000-0002-6888-6560, Beijing Sport University), Jingjing Yu (0000-0001-8938-4298, Beijing Sport University), Zhenxing Kong (0000-0002-7945-7219, Beijing Sport University), Haiyun Liu (0000-0002-8082-6122, Beijing Sport University), Yimin Zhang (0000-0003-3820-380X, Beijing Sport University, corresponding author)
Year2024
Volume12
Pages1451101-1451101
Publication date2024-09-19
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1451101
PMID39363984
OpenAlexW4402656705
LanguageEN
References cited52

Purpose Aimed to assess the impact of wearable device-based aerobic exercise on the physical and mental well-being of women with breast cancer (BC) undergoing chemotherapy. Methods Forty adult women with BC who underwent anthracycline-based chemotherapy were randomly allocated to the exercise group ( n = 21) or the control group ( n = 19). Both groups received standard health education and oncology care. In addition, the exercise group wore wearable devices to engage in moderate to high-intensity (50–90% HRmax) aerobic exercise during chemotherapy, while the control group did not carry out exercise intervention. Health-related physical fitness level, physical activity energy expenditure (PAEE), anxiety and depression scores, sleep quality, cancer-related fatigue, and overall quality of life (QoL), were assessed both before (prior to the first chemotherapy session) and after (prior to the fifth chemotherapy session) the exercise intervention. Exercise-related adverse events, exercise compliance, number and severity of gastrointestinal reactions and myelosuppression occurred were recorded during the exercise intervention. Results After the intervention, compared to the control group, the exercise group (1) had significantly higher relative VO 2 peak ( p = 0.003) and handgrip strength ( p < 0.001); (2) had significantly higher PAEE ( p < 0.001); (3) had a significantly lower scores in anxiety ( p = 0.007), depression ( p = 0.028), sleep quality in domains of subjective sleep quality ( p = 0.010), sleep disturbances ( p = 0.004), daytime dysfunction ( p = 0.007), cancer-related fatigue in domains of physical ( p < 0.001) and affective ( p < 0.001); and (4) had a significantly lower scores in QoL in domains of physical well-being ( p < 0.001) and emotional well-being ( p = 0.019), while a significantly higher scores in functional well-being ( p < 0.001). Patients in the exercise group experienced less severe gastrointestinal reactions ( p = 0.028) and myelosuppressive symptoms ( p < 0.001) than that in the control group. Patients in the exercise group had no serious exercise-related adverse events, with a mean exercise adherence of 81.8%. Conclusion Wearable device-based aerobic exercise during chemotherapy can be an effective adjunctive therapy to improve physical and mental health in BC patients. Clinical trial registration https://www.chictr.org.cn/showproj.html?proj=200247 , Identifier: ChiCTR2300073667

Aerobic exercise · Anxiety · Breast cancer · Cancer · Physical therapy · Psychiatry · Randomized controlled trial · Cancer Risks and Factors · Cancer survivorship and care · Cancer-related cognitive impairment studies · Medicine · Nursing · Internal Medicine

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