Peripartum cocaine use and adverse pregnancy outcome
Bibliographic Data
| ID | 22474816 |
|---|---|
| Authors | Bertis B Little (0000-0002-6485-4641, The University of Texas Southwestern Medical Center, corresponding author), L M Snell (0000-0001-9890-6588, The University of Texas Southwestern Medical Center), Kenneth J Trimmer (The University of Texas Southwestern Medical Center), Susan M Ramin (The University of Texas Southwestern Medical Center), Fred Ghali (The University of Texas Southwestern Medical Center), Craig A Blakely (Public Policy Institute of California), Andrea Garret (Parkland Health & Hospital System) |
| Year | 1999 |
| Volume | 11 |
| Issue | 5 |
| Pages | 598-602 |
| Publication date | 1999-09-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 1042-0533 • E-ISSN: 1520-6300 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/(sici)1520-6300(199909/10)11:5<598::aid-ajhb3>3.0.co;2-l |
| PMID | 11533978 |
| OpenAlex | W1968923251 |
| Language | EN |
| References cited | 21 |
The objective of the study was to analyze possible adverse effects of peripartum cocaine use on maternal and fetal outcomes. Informed consent was given by 720 (97%) of 740 women who delivered consecutively at a large urban public hospital to test an umbilical cord blood sample for the presence of non-medically administered drugs of abuse and alcohol and to be interviewed for the study. Samples were tested for the presence of a cocaine metabolite (benzoylecgonine-BZE) by radioimmunoassay. The presence of other substances of abuse (alcohol, methamphetamine, opiates) resulted in exclusion from the sample of 143 subjects. Thus, in this cohort analysis, drug-free controls (N = 469) were compared to those positive for cocaine only (N = 108). Peripartum exposure to cocaine only, and no other substances of abuse, was associated with an increased frequency of abruptio placentae (1.9% vs 0% for control, P < 0.004), thick meconium stained amniotic fluid (3.9% vs 0.7% for controls, P < 0.006), premature rupture of membranes (P < 0.02), genitourinary anomalies (OR = 3.6, P < 0.05), abdominal wall defects (OR = 4.4, P < 0.01) and increased frequency of low birth weight (OR = 2.0, P < 0.02). These are important findings because previous studies have been complicated by the confounding effects of other substances of abuse. Am. J. Hum. Biol. 11:598-602, 1999. Copyright 1999 Wiley-Liss, Inc.
Adverse effect · Amniotic fluid · Benzoylecgonine · Fetus · Meconium · Metabolite · Obstetrics · Pregnancy · Vomiting · Cannabis and Cannabinoid Research · Gestational Diabetes Research and Management · Internal Medicine · Medicine · Physiology · Prenatal Substance Exposure Effects
| Highly cited | No |
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