Astilbin from Smilax china L. remarkably inhibits LPS-induced endometritis in rats via blocking positive feedback between TLR4 and IL-6R signalling pathways in a PPAR-γ-dependent manner

Bibliographic Data

ID22917397
AuthorsHaixing Feng (0000-0002-6580-3280, Shenzhen University Health Science Center), Chunni Li (Southern Medical University), Jingyao Chen (0000-0002-0749-2656, Nanfang Hospital), Zhiwen Li (0000-0001-7570-3809, Southern Medical University), Xuan Ye (0000-0002-7650-7049, Southern Medical University), Lianbing Hou (0000-0001-7256-0996, Southern Medical University), Chunxia Wang (0000-0003-4550-5208, Nanfang Hospital, corresponding author), Chuqi Hou (0000-0002-9125-9661, Southern Medical University, corresponding author), Wenqin Liu (0009-0009-1200-781X, Southern Medical University, corresponding author)
Year2025
Volume348
Pages119861
Publication date2025-05-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119861
PMID40274031
OpenAlexW4409686582
LanguageEN
Citations received2
References cited26

Overall, our results demonstrated that ATB can significantly inhibit endometritis in rats, presumably through interfering with NF-κB and STAT3 signal transduction in a PPAR-γ-dependent manner, blocking the positive feedback between NF-κB and STAT3 signalling. Our findings provide new evidences for developing the ATB, the main compound identified from FSCR, as a potential therapeutic agent for endometritis.

Biological activity · Biology · Blocking (statistics) · In vitro · Peroxisome proliferator-activated receptor · Pharmacognosy · Receptor · Signal transduction · TLR4 · Traditional medicine · Biochemistry · Cell Biology · Computer Science · Endocrinology · Internal Medicine · Medicine · Pharmacology · Phytochemical Studies and Bioactivities · Phytochemistry and Bioactive Compounds · Seaweed-derived Bioactive Compounds

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