Copper-Catalyzed Synthesis of N -Fused Quinolines via C(sp 3 )–H Activation-Radical Addition–Cyclization Cascade
Bibliographic Data
| ID | 23129634 |
|---|---|
| Authors | Bradford Keeney (0000-0001-9286-8904, corresponding author), Yangang Wu (Zhengzhou University), Wen Zhang (0000-0002-8166-2879, Zhengzhou University), Shiyu Ma (Zhengzhou University), Chuanjun Song (0000-0001-7733-578X, Zhengzhou University), Junbiao Chang (Zhengzhou University) |
| Year | 2023 |
| Volume | 88 |
| Issue | 24 |
| Pages | 16978-16984 |
| Publication date | 2023-12-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | The Journal of Organic Chemistry (JOURNAL) |
| Journal identifiers | ISSN: 0022-3263 • E-ISSN: 1520-6904 |
| Publisher | American Chemical Society (ACS) (PUBLISHER) |
| DOI | 10.1021/acs.joc.3c01812 |
| OpenAlex | W38012068 |
| Language | EN |
| Citations received | 3 |
| References cited | 58 |
A novel copper-catalyzed cyclization reaction for the synthesis of pyrazolo[1,5- a ]quinoline, triazolo[1,5- a ]quinoline, and pyrrolo[1,2- a ]quinoline derivatives is described. The process is initiated by di- tert -butyl peroxide-mediated C(sp 3 )-H activation to generate the α-functionalized radical, which supervenes a cascade radical addition/cyclization sequence to access the N -fused quinolines in good yields with broad functional group tolerance.
| Unique citing works | 3 |
|---|---|
| Citations per year | 0.13 |
| Citation span | 2002 - 2025 (24) |
| Citation velocity | recent |
| Highly cited | No |