Resurrection of vitamin D deficiency and rickets
Bibliographic Data
| ID | 23320384 |
|---|---|
| Authors | Michael F Holick (0000-0001-6023-9062, Boston Medical Center, corresponding author) |
| Year | 2006 |
| Volume | 116 |
| Issue | 8 |
| Pages | 2062-2072 |
| Publication date | 2006-08-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Clinical Investigation (JOURNAL) |
| Journal identifiers | ISSN: 0021-9738 • E-ISSN: 1558-8238 |
| Publisher | American Society for Clinical Investigation (PUBLISHER • US) |
| DOI | 10.1172/jci29449 |
| PMID | 16886050 |
| PMCID | PMC1523417 |
| OpenAlex | W2112056917 |
| Language | EN |
| Citations received | 63 |
| References cited | 1 |
The epidemic scourge of rickets in the 19th century was caused by vitamin D deficiency due to inadequate sun exposure and resulted in growth retardation, muscle weakness, skeletal deformities, hypocalcemia, tetany, and seizures. The encouragement of sensible sun exposure and the fortification of milk with vitamin D resulted in almost complete eradication of the disease. Vitamin D (where D represents D2 or D3) is biologically inert and metabolized in the liver to 25-hydroxyvitamin D [25(OH)D], the major circulating form of vitamin D that is used to determine vitamin D status. 25(OH)D is activated in the kidneys to 1,25-dihydroxyvitamin D [1,25(OH)2D], which regulates calcium, phosphorus, and bone metabolism. Vitamin D deficiency has again become an epidemic in children, and rickets has become a global health issue. In addition to vitamin D deficiency, calcium deficiency and acquired and inherited disorders of vitamin D, calcium, and phosphorus metabolism cause rickets. This review summarizes the role of vitamin D in the prevention of rickets and its importance in the overall health and welfare of infants and children.
Calcium · Osteomalacia · Rickets · Tetany · Vitamin · Vitamin D and neurology · vitamin D deficiency · Bone health and osteoporosis research · Endocrinology · Internal Medicine · Medicine · Vitamin C and Antioxidants Research · Vitamin D Research Studies
Frequency of common factors leading to nutritional rickets among children under 2 years of age
Detection the genetic variation of vitamin D binding protein (VDBP) gene in women with osteoporosis in Mosul City
Different comparison of mean SR. homocystene in serum 25 – hydroxyvitamin D in acute stroke
Severe Vitamin D-deficiency and the Health of North China Children
The material body
Disorders of Calcium and Magnesium Metabolism
Reconstructing Extinct Hominin Diets
Evaluation, Treatment, and Prevention of Vitamin D Deficiency
Using Nature and Outdoor Activity to Improve Children's Health
Vitamin D Deficiency
Vitamin D deficiency
Maternal and child undernutrition
A multi-analytical approach to fetal/neonatal birth trauma and possible metabolic stress in a Neolithic alpine mobility context (3932–3653 cal BCE)
Vitamin D deficiency in northern Taiwan
Predictors of Maternal Knowledge, Attitude, and Practices Toward Vitamin D Supplements in Saudi Infants and Toddlers
Neurological Symptoms That May Represent a Warning in Terms of Diagnosis and Treatment in a Group of Children and Adolescents with Vitamin D Deficiency
Vitamin D status of White pregnant women and infants at birth and 4 months in North West England
Vitamin D supplementation is associated with higher serum 25 OHD in A sian and W hite infants living in V ancouver, C anada
Very high vitamin D supplementation rates among infants aged 2 months in Vancouver and Richmond, British Columbia, Canada
Environmental and Genetic Determinants of Serum 25(OH)-Vitamin D Levels during Pregnancy and Early Childhood
Effects of Perceived Benefit on Vitamin D Supplementation Intention
Heightened attention to supplementation is needed to improve the vitamin D status of breastfeeding mothers and infants when sunshine exposure is restricted
Vitamin D status among adults in the Aegean region of Turkey
Hypovitaminosis D in healthy children in Central Thailand
Positive impact on vitamin D related lifestyle of medical advice in pregnant Somali-born women and new mothers
Effects of Forest Therapy on Health Promotion among Middle-Aged Women
Growing up in the oasis
Smaller long bone cross-sectional size in people who died of tuberculosis
The rachitic tooth
New findings in the identification of adult vitamin D deficiency osteomalacia
A joint medico-historical and paleopathological perspective on vitamin D deficiency prevalence in post-Medieval Netherlands
Nutrition-related health problems in a wealthy 17–18th century German community in Jelgava, Latvia
Is dietary deficiency of calcium a factor in rickets? Use of current evidence for our understanding of the disease in the past
Differential diagnosis of metabolic disease in a commingled sample from 19th century Hisban, Jordan
Probable micronutrient deficiency diseases in a rural community. The nonadults of Mary’s Nativity church, 16th century, Trentino Alto-Adige, Italy
Hardship in the Western regions
Rickets and the industrial revolution in France
Food system strategies for preventing micronutrient malnutrition
Vitamin D deficiency in refugee children from conflict zones
Contagion in the Capital
Not by Selection Alone
Biocultural perspectives of vitamin D deficiency in the past
The multifactor pelvis
Controlled trials of vitamin D, causality and type 2 statistical error
Vitamin D supplementation in young children
Serum 25-hydroxyvitamin D concentrations in 16-year-old Icelandic adolescent and its association with bone mineral density
Vitamin D, sun, sunbeds and health
Wild fish consumption and latitude as drivers of vitamin D status among Inuit living in Nunavik, northern Québec
Rickets in a non-industrialised Iberian population
Solar Ultraviolet Radiation and Vitamin D
The evolution of light skin color
North and south
Latitude, urbanization, age, and sex as risk factors for vitamin D deficiency disease in the Roman Empire
In sickness and in death
More than metabolic
Micro‐CT assessment of dental mineralization defects indicative of vitamin D deficiency in two 17th–19th century Dutch communities
Be Proactive, Perform Regular Skin Self‐Exams and Protect Yourself”
Bringing home the bacon? Regional nutrition, stature, and gender in the industrial revolution1
Rural Rickets
Growth and vitamin D deficiency in a population from 19th century Birmingham, England
Knock-knees
Evaluation and interpretation of residual rickets deformities in adults
Ancient Vitamin D Deficiency
| Unique citing works | 63 |
|---|---|
| Citations per year | 3,32 |
| Citation span | 2007 - 2026 (20) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 60 |