Understanding the Complex of Suicide in Depression
From Research to Clinics
Bibliographic Data
Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most prevalent, by affecting approximately 15–17% of the population and showing a high suicide risk rate equivalent to around 15%. The present comprehensive overview aims at evaluating main research studies in the field of MDD at suicide risk, by proposing as well as a schematic suicide risk stratification and useful flow-chart for planning suicide preventive and therapeutic interventions for clinicians.Methods A broad and comprehensive overview has been here conducted by using PubMed/Medline, combining the search strategy of free text terms and exploded MESH headings for the topics of ‘Major Depressive Disorder’ and ‘Suicide’ as following: (( suicide [Title/Abstract]) AND ( major depressive disorder [Title/Abstract])). All articles published in English through May 31, 2019 were summarized in a comprehensive way.Results Despite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (i.e., interpersonal, professional, financial, as well as psychiatric disorders), epigenetic, the hypothalamic-pituitary-adrenal stress-response system, the involvement of the monoaminergic neurotransmitter systems, particularly the serotonergic ones, the lipid profile, neuro-immunological biomarkers, the Brain-derived neurotrophic factor and other neuromodulators.Conclusion The present overview reported that suicide is a highly complex and multifaceted phenomenon in which a large plethora of mechanisms could be variable implicated, particularly amongst MDD subjects. Beyond these consideration, modern psychiatry needs a better interpretation of suicide risk with a more careful assessment of suicide risk stratification and planning of clinical and treatment interventions.
Cognition · Major depressive disorder · Medical emergency · Poison control · Psychiatry · Psychological intervention · Psychosocial · Clinical Psychology · Medicine · Psychology · Suicide and Self-Harm Studies · Treatment of Major Depression · Tryptophan and brain disorders
Prevalence of depression in patients on hemodialysis
Dietary pattern among staff members and its relation to depression, Minia University, Egypt
Life Satisfaction and Suicidal Ideation Among Chinese College Students During the Recurrent Outbreak of Covid-19
PTSD in French Adolescent Victims Following the London Attack in March 2017
Teen Advisory Council Survey's Factors Associated With Self-Harming Thoughts
Psychotherapists' Knowledge of Guideline Recommendations for the Treatment of Depressed Suicidal Patients
Increased Asymmetric Perfusion of the Cerebral Cortices and Thalamus Indicates Individuals at Risk for Bipolar Disorder
Associations of Suicide Risk and Community Integration Among Patients With Treatment-Resistant Depression
Examining Anxiety, Sleep Quality, and Physical Activity as Predictors of Depression among University Students from Saudi Arabia during the Second Wave of the Covid-19 Pandemic
Predictors of Suicide Re-Attempt in a Spanish Adolescent Population after 12 Months’ Follow-Up
Transition from Depression to Suicidal Attempt in Young Adults
Evaluation of Anxiety, Suicidal Risk, Daily Stress, Empathy, Perceived Emotional Intelligence, and Coping Strategies in a Sample of Spanish Undergraduates
The psychological impact of Covid-19 on the mental health in the general population
The Effects of Type III Traumatic Stressors of the Protracted Conflict and Prolonged Covid-19 on Syrians Internally Displaced
Social network typologies moderate the association of loneliness with depressive symptomatology in middle-aged and older adults
Network and Exploratory Factorial Analysis of the Depression Clinical Evaluation Test
Change of Circulating Vascular Endothelial Growth Factor Level and Reduction of Anhedonia Are Associated in Patients With Major Depressive Disorder Treated With Repetitive Transcranial Magnetic Stimulation
Mother’s Loneliness
Prevalence and Factors Associated With Depression and Suicidal Ideation During the Covid-19 Pandemic Among University Students in Uganda
Suicidal Ideation Among Adolescents—The Role of Sexual Abuse, Depression, and Impulsive Behavior
Childhood Maltreatment, Stressful Life Events, Cognitive Emotion Regulation Strategies, and Non-suicidal Self-Injury in Adolescents and Young Adults With First-Episode Depressive Disorder
STAIR Plus Narrative Therapy-Adolescent Version (SNT-A) in An 11-Year-Old Girl With PTSD and Suicidal Behaviors Following Rape/Sexual Assault
The Association of Abuse and Depression With Suicidal Ideation in Chinese Adolescents
Suicidality and Quality of Life in Treatment-Resistant Depression Patients in Latin America
The relationship between patterns of depression changes and suicide among older women in Korea
Learning From Artemisia’s Lucretia
Solving the gender paradox in adolescent suicide
Feasibility and Preliminary Efficacy of a New Online Self-Help Intervention for Depression among Korean College Students’ Families
Childhood Trauma and Non-suicidal Self-Injury Among Chinese Adolescents
Persistent Depressive Disorder-Related Effect of Sleep Disorder on the Highest Risk of Suicide in Taiwan, 2000–2015
Differences in Influencing Factors Between Non-suicidal Self-Injury and Suicide Attempts in Chinese Adolescents
Plasma Vegf Concentrations and Ketamine's Effects on Suicidal Ideation in Depression With Suicidal Ideation
Associations between somatic symptoms and suicidal behavior
Age-specific associations between serum cholesterol levels and suicidal behaviors in patients with depressive disorders
Acceptability and content validity of suicidality screening items
Incorporating multi-stage diagnosis status to mine associations between genetic risk variants and the multi-modality phenotype network in major depressive disorder
Bilateral repetitive transcranial magnetic stimulation ameliorated sleep disorder and hypothalamic–pituitary–adrenal axis dysfunction in subjects with major depression
Effects of Financial Expenditure of Prefectures/Municipalities on Regional Suicide Mortality in Japan
Risk factors for suicidal attempts in a sample of outpatients with treatment-resistant depression
The survey of the status of self-stigma of depression and its relationship with demographic factors in Gonabad, Iran
Athlete Identity and Mental Health of Student Athletes during Covid-19
Suicidal Ideation Is Associated With Reduced Functional Connectivity and White Matter Integrity in Drug-Naïve Patients With Major Depression
The role of Theory of Mind in the transition towards suicidal attempts in youth NSSI
Serum Lipid Levels and Suicide Attempts Within 2 Weeks in Patients With Major Depressive Disorder
Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes
Effectiveness of horticultural therapy in aged people with depression
Peer pressure
Patient-centered addiction medicine
Attention to negative information and PTSSs during the Covid-19
The mediating role of early maladaptive schemas in the relationship between early childhood trauma and alexithymia
Relationships among adult playfulness, stress, and coping during the Covid-19 pandemic
The relationship between creative mindsets and malevolent creativity among adolescents
The role of extraversion and neuroticism for experiencing stress during the third wave of the Covid-19 pandemic
Exploring the role of family communication time in the association between family dinner frequency and adolescent psychological distress
Effect of Covid-19 outbreak on anxiety among students of higher education; A review of literature
Predictive ability of the attitude towards plastic surgeries and self – image editing behavior of symptoms of body dysmorphic disorder among University students
The influence of pessimism on adverse network behavior during Covid-19
Personality traits and psychological well-being as moderators of the relationship between stressors and negative affect
Electrocortical evidence of biased attention to safety cues and stimuli among worriers
Metacognitive features and cognitive distortions of the patients with major depression
Testing a bifactor model and measurement invariance of the cognitive avoidance questionnaire in Chinese adolescents
Covid-19 related fear and mental health in Indian sample
Examining the relationships between emotional disorder symptoms in a mixed sample of community adults and patients
Can social support be improved in people with a severe mental illness? A systematic review and meta-analysis
Uncovering the heterogeneous effects of depression on suicide risk conditioned by linguistic features
Verbal learning, working memory, and attention/vigilance may be candidate phenotypes of bipolar II depression in Chinese Han nationality
Exploring How the Dark Triad and Curiosity Shape the Trajectory of Affective Events in Response to Covid-19 Stress and Psychological Well-Being
Socioeconomic status and suicidal behaviour in the UK Biobank
The influence of residential Environment and residential experience on psychological depression in older adults
The U-Shape Association Between Noise and Individual Depression
Suicide on Italian Instagram
Advancing the Next Generation of Research on Self-Silencing and Depression
Detecting signs of depression on social media
Re-evaluating national suicide prevention month
Prevalence of depression among adolescents in rural communities of Mexico
Is there a correlation between the spirituality and the suicide probability in individuals with mental illness? A sample from Turkey
Psychological correlates distinguish suicide ideation, suicide planning, and suicide attempts among young adults
E-learning as a tool of suicide prevention training
Association between the dispositional optimism and depression in young people
Necesito Un Psicólogo
The Meaning of Social Support for Mental Health Service-Users
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Inflammation and minority stress
The variable nature of cognitive control
Global variation in the prevalence and incidence of major depressive disorder
The epidemiology of major depressive episodes
Cognitive impairment in depression
A Psychobiological Model of Temperament and Character
Risks of all-cause and suicide mortality in mental disorders
Risk factors for suicide in individuals with depression
Suicide
Advancing understanding of executive function impairments and psychopathology
The FDA “Black Box” Warning on Antidepressant Suicide Risk in Young Adults
Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function
| Unique citing works | 83 |
|---|---|
| Citations per year | 13,83 |
| Citation span | 2020 - 2026 (7) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 71 |