Why Sleep Is Important for Health
A Psychoneuroimmunology Perspective
Bibliographic Data
| ID | 23325944 |
|---|---|
| Authors | Michael R Irwin (0000-0002-1502-8431, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, California 90095, corresponding author) |
| Year | 2015 |
| Volume | 66 |
| Issue | 1 |
| Pages | 143-172 |
| Publication date | 2015-01-03 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Annual Review of Psychology (JOURNAL) |
| Journal identifiers | ISSN: 0066-4308 • E-ISSN: 1545-2085 |
| Publisher | Annual Reviews (PUBLISHER • US) |
| DOI | 10.1146/annurev-psych-010213-115205 |
| PMID | 25061767 |
| OpenAlex | W2125158184 |
| Language | EN |
| Citations received | 91 |
| References cited | 186 |
Sleep has a critical role in promoting health. Research over the past decade has documented that sleep disturbance has a powerful influence on the risk of infectious disease, the occurrence and progression of several major medical illnesses including cardiovascular disease and cancer, and the incidence of depression. Increasingly, the field has focused on identifying the biological mechanisms underlying these effects. This review highlights the impact of sleep on adaptive and innate immunity, with consideration of the dynamics of sleep disturbance, sleep restriction, and insomnia on (a) antiviral immune responses with consequences for vaccine responses and infectious disease risk and (b) proinflammatory immune responses with implications for cardiovascular disease, cancer, and depression. This review also discusses the neuroendocrine and autonomic neural underpinnings linking sleep disturbance and immunity and the reciprocal links between sleep and inflammatory biology. Finally, interventions are discussed as effective strategies to improve sleep, and potential opportunities are identified to promote sleep health for therapeutic control of chronic infectious, inflammatory, and neuropsychiatric diseases.
Cognition · Disease · Immune system · Infectious disease (medical specialty) · Insomnia · Psychiatry · Psychoneuroimmunology · Sleep (system call) · Sleep deprivation · Sleep disorder · Sleep restriction · Circadian rhythm and melatonin · Immunology · Medicine · Neuroscience · Psychology · Sleep and related disorders · Stress Responses and Cortisol
Exploring the importance of bodyset for the psychedelic experience and beyond
Perceived Discrimination and Adolescent Sleep in a Community Sample
Income, mental health, and sleep quality in sexual minorities in the United Kingdom
Assessment of Sleep Quality in Adolescents with Overweight and Obesity Using the Adolescent Sleep Hygiene Scale (ASHS)
Health consequences of shift work and insufficient sleep
Research on the correlation of immunity in patients with chronic insomnia
The mediating roles of cognitive emotion regulation and resilience in the association between life events and sleep quality among medical students
Efficacy of acupuncture treatment for breast cancer-related insomnia
Neurological Symptoms and Their Associations With Inflammatory Biomarkers in the Chronic Phase Following Traumatic Brain Injuries
Determinants of Poor Sleep Quality During the Covid-19 Pandemic Among Women Attending Antenatal Care Services at the Health Facilities of Debre Berhan Town, Ethiopia
Association of Insufficient or Excess Sleep with Type 2 Diabetes Mellitus in the Presence of Periodontitis
Self-Rated Health and Inflammation
Don’t sleep on it
Influence of lifestyle patterns on depression among adults with diabetes
Recent Stressful Life Events and Perceived Stress as Serial Mediators of the Association between Adverse Childhood Events and Insomnia
The Sleep-Immune Crosstalk in Health and Disease
The 2024 report of the Lancet Countdown on health and climate change
Inflammation
Lovesick
So Close and Yet So Irritating
Discrimination and Sleep
Mediating effect of depression and acute stress between exposure to Israel-Gaza war media coverage and insomnia
Association between sleep patterns and galectin-3 in a Chinese community population
A U-shaped relationship between nighttime sleep duration and new-onset emotional, nervous, or psychiatric problems
Health behaviours the month prior to Covid-19 infection and the development of self-reported long Covid and specific long Covid symptoms
Association between sleep quality and quality of life in Singapore
The Relationship between Cognitive Function, Lifestyle Behaviours and Perception of Stress during the Covid-19 Induced Confinement
Age and Hair Cortisol Levels as Predictors of Sars-CoV-2 Infection
Is Bedtime Procrastination Related to Multidimensional Sleep Health? Evidence from Samples of Different Educational Stages (Aged 10–25) in China
From infected to recovered
Multilevel analysis of sleep arrangements and psychological well-being among older couples in Taiwan
Sleep Disturbances and Delayed Sleep Timing are Associated with Greater Post-Traumatic Stress Symptoms in Youth Following Hurricane Harvey
Effects of music-based interventions on sleep quality in older adults
Insights Gained in the Aftermath of the Covid-19 Pandemic
Role of social support in the relationship between resilience and sleep quality among cancer patients
Promoting Health by Improving Subjective Sleep Quality? Reduction in Depressive Symptoms and Inflammation as Potential Mechanisms and Implications for Trauma-Exposed Persons
Associations between sleep duration trajectories and physical dysfunction among middle-aged and older Chinese adults
Association of meeting 24-hour movement guidelines with anxiety and depressive symptoms in adults
Level of Physical Activity, Sleep Quality and Use of Personal Protective Equipment of Students at Wroclaw Medical University during the Covid-19 Pandemic
Sleep Traits, Night Shift Work and Lung Cancer Risk among Women
Correlation between Sleep Quality and Frailty Status among Middle-Aged and Older Taiwanese People
Rising temperatures erode human sleep globally
A low-threshold sleep intervention for improving sleep quality and well-being
Impaired Well-Being and Insomnia as Residuals of Resolved Medical Conditions
The relationship between perceived stress and bedtime procrastination among Chinese college students
The association between sleep duration trajectories and successful aging
Covid-19-Related Factors Associated with Sleep Disturbance and Suicidal Thoughts among the Taiwanese Public
Sleep and mental health among Chinese adolescents
CD4+ T cell dysregulation in major depressive disorder is associated with sleep disturbance
Predicting SSRI-Resistance
Cultivating intention to pursue health-related studies among a pilot group of high schoolers
The impact of insomnia on the development of arterial hypertension
Physical activity and happiness of college students
Spillover Effect of the Internet on Trade Performance Based on a Vision of the Public's Sleep Health
Weekly work hours and cervical spine dysfunction among video display terminal workers
Sleep duration and the risk of new-onset arthritis in middle-aged and older adult population
Insomnia and sleep duration on Covid-19 susceptibility and hospitalization
A study on the association between sleep quality and mental health of township healthcare workers from the perspective of social support
Longitudinal trajectories and risk factors of insomnia symptoms among Chinese bus drivers
How do low-carbon city policies shape older adults health? Evidence from environmental and mobility pathways in China
Moderated serial mediation effects of adaptation problems, academic stress, and interpersonal relationships on the sleep quality of early-year university students
Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness
Ethics of sleep tracking
Age-dependent associations among insomnia, depression, and inflammation in nurses
Acute and chronic sleep deprivation in residents
Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males
Multiplex influences on vigilance and biochemical variables induced by sleep deprivation
Changes in the lifestyle behavior and anthropometrics of university students after the first year
Consensus statement on developmentally appropriate policy and practice for adolescents in foster care
Discrimination, Sleep, and Stress Reactivity
The translation and validation of the Organ Transplant Symptom and Well-Being Instrument in China
The influence of physical activity on sleep quality in people living with HIV
Associations of total daily working hours encompassing unpaid care and domestic work with nonrestorative sleep and mental health in middle-aged Japanese men and women
Sleep and Inflammation During Adolescence
Sleep Disturbance as a Mediator of Lung Cancer Stigma on Psychological Distress and Physical Symptom Burden
Sleep, Positive Affect, and Circulating Interleukin-6 in Women With Temporomandibular Joint Disorder
Reciprocal Relationship Between Sleep Macrostructure and Evening and Morning Cellular Inflammation in Rheumatoid Arthritis
Ten Tips to Hurdle the Injuries and Illnesses During Major Athletics Championships
Why is personality tied to sleep quality? A biometric analysis of twins
Longitudinal Association Among Sleep Problems and Depressive Symptoms
Examining the Reciprocal Association Between Worry and Sleep
Subjective Social Status and Adolescent Health
Sleep Quality and Sleep Behaviors in Varsity Athletes
Interactions between co-sleeping, sleep quality, and relationship health
Sleep during travel balances individual sleep needs
Individual sleep need is flexible and dynamically related to cognitive function
Lifestyle behavior of physiotherapy students from Ecuador upon admission to higher education
Longitudinal interplays between basic psychological need satisfaction and sleep among older adults in China
Effects of stress on sleep quality
The Human Sleep Paradox
Discrimination in Middle Eastern and North African Americans predicts Worse Mental Health as Mediated by Sleep
Diagnostic and Statistical Manual of Mental Disorders
Sleep duration predicts cardiovascular outcomes
The Role of Actigraphy in the Study of Sleep and Circadian Rhythms
Origin and physiological roles of inflammation
The Insomnia Severity Index
Inflammation and Atherosclerosis
Insomnia as a predictor of depression
Epidemiology of insomnia
Loneliness, Social Network Size, and Immune Response to Influenza Vaccination in College Freshmen.
Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders
Sleep Health
Mortality Associated With Sleep Duration and Insomnia
Psychological Stress and Antibody Response to Influenza Vaccination
Sleep Enhances the Human Antibody Response to Hepatitis A Vaccination
Partial sleep deprivation reduces natural killer cell activity in humans
Overnight Changes of Immune Parameters and Catecholamines Are Associated With Mood and Stress
Insomnia and High-Sensitivity C-Reactive Protein
C-reactive protein Levels and Sleep Disturbances
Circadian Immune Measures in Healthy Volunteers
Insomnia in HIV Infection
Disordered Sleep, Nocturnal Cytokines, and Immunity in Alcoholics
Chronic Insomnia and Immune Functioning
Healthy Older Adults’ Sleep Predicts All-Cause Mortality at 4 to 19 Years of Follow-Up
From stress to inflammation and major depressive disorder
| Unique citing works | 91 |
|---|---|
| Citations per year | 8,27 |
| Citation span | 2015 - 2026 (12) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 78 |