National, regional, and global burdens of disease from 2000 to 2016 attributable to alcohol use

A comparative risk assessment study

Bibliographic Data

ID23337883
AuthorsKevin D Shield (0000-0003-1871-8849, Centre for Addiction and Mental Health, corresponding author), Kevin Shield, Jurgen Manthey (0000-0003-1231-3760, Universität Hamburg), Jakob Manthey, Margaret Rylett (0000-0001-8300-5955, Centre for Addiction and Mental Health), Charlotte Probst (0000-0003-4360-697X, Centre for Addiction and Mental Health), Ashley Wettlaufer (0000-0003-1762-7021, Centre for Addiction and Mental Health), Charles D H Parry, Charles Parry (0000-0001-9787-2785, South African Medical Research Council), Jurgen Rehm (0000-0001-5665-0385, Centre for Addiction and Mental Health)
Year2020
Volume5
Issue1
Pagese51-e61
Publication date2020-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueThe Lancet Public Health (JOURNAL)
Journal identifiersISSN: 2468-2667 • E-ISSN: 2468-2667
PublisherElsevier BV (PUBLISHER)
DOI10.1016/s2468-2667(19)30231-2
PMID31910980
OpenAlexW2997589337
LanguageEN
Citations received100
References cited27

BACKGROUND: Alcohol use has increased globally, with varying trends in different parts of the world. This study investigates gender, age, and geographical differences in the alcohol-attributable burden of disease from 2000 to 2016. METHODS: This comparative risk assessment study estimated the alcohol-attributable burden of disease. Population-attributable fractions (PAFs) were estimated by combining alcohol exposure data obtained from production and taxation statistics and from national surveys with corresponding relative risks obtained from meta-analyses and cohort studies. Mortality and morbidity data were obtained from the WHO Global Health Estimates, population data were obtained from the UN Population Division, and human development index (HDI) data were obtained from the UN Development Programme. Uncertainty intervals (UIs) were estimated using a Monte Carlo-like approach. FINDINGS: Globally, we estimated that there were 3·0 million (95% UI 2·6-3·6) alcohol-attributable deaths and 131·4 million (119·4-154·4) disability-adjusted life-years (DALYs) in 2016, corresponding to 5·3% (4·6-6·3) of all deaths and 5·0% (4·6-5·9) of all DALYs. Alcohol use was a major risk factor for communicable, maternal, perinatal, and nutritional diseases (PAF of 3·3% [1·9-5·6]), non-communicable diseases (4·3% [3·6-5·1]), and injury (17·7% [14·3-23·0]) deaths. The alcohol-attributable burden of disease was higher among men than among women, and the alcohol-attributable age-standardised burden of disease was highest in the eastern Europe and western, southern, and central sub-Saharan Africa regions, and in countries with low HDIs. 52·4% of all alcohol-attributable deaths occurred in people younger than 60 years. INTERPRETATION: As a leading risk factor for the burden of disease, alcohol use disproportionately affects people in low HDI countries and young people. Given the variations in the alcohol-attributable burden of disease, cost-effective local and national policy measures that can reduce alcohol use and the resulting burden of disease are needed, especially in low-income and middle-income countries. FUNDING: None.

Attributable risk · Burden of disease · Cohort · Cohort study · Disease burden · Environmental health · Population · Alcohol Consumption and Health Effects · Demography · Internal Medicine · Medicine · Prenatal Substance Exposure Effects · Substance Abuse Treatment and Outcomes