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Do prevention interventions reduce HIV risk behaviours among people living with HIV? A meta-analytic review of controlled trials

Bibliographic Data

ID23346366
AuthorsNicole Crepaz (0000-0002-6940-9846, Division of Chemistry), Cynthia M Lyles (0000-0002-4203-0414, Division of Chemistry), Richard J Wolitski (Division of Chemistry), Warren F Passin (Division of Chemistry), Sima M Rama (Division of Chemistry), Jeffrey H Herbst (0000-0002-0432-2643, Division of Chemistry), David W Purcell (0000-0001-8125-5168, Division of Chemistry), Robert M Malow (Florida International University), Ron Stall (0000-0002-4741-4396, Centers for Disease Control and Prevention, corresponding author)
Year2006
Volume20
Issue2
Pages143-157
Publication date2006-01-09
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS (JOURNAL)
Journal identifiersISSN: 0269-9370 • E-ISSN: 1473-5571
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/01.aids.0000196166.48518.a0
PMID16511407
OpenAlexW2046141153
LanguageEN
Citations received100
References cited52

OBJECTIVE: To conduct a meta-analytic review of HIV interventions for people living with HIV (PLWH) to determine their overall efficacy in reducing HIV risk behaviours and identify intervention characteristics associated with efficacy. METHODS: Comprehensive searches included electronic databases from 1988 to 2004, hand searches of journals, reference lists of articles, and contacts with researchers. Twelve trials met the stringent selection criteria: randomization or assignment with minimal bias, use of statistical analysis, and assessment of HIV-related behavioural or biologic outcomes at least 3 months after the intervention. Random-effects models were used to aggregate data. RESULTS: Interventions significantly reduced unprotected sex [odds ratio (OR), 0.57; 95% confidence interval (CI) 0.40-0.82] and decreased acquisition of sexually transmitted diseases (OR, 0.20; 95% CI, 0.05-0.73). Non-significant intervention effects were observed for needle sharing (OR, 0.47, 95% CI, 0.13-1.71). As a whole, interventions with the following characteristics significantly reduced sexual risk behaviours: (1) based on behavioural theory; (2) designed to change specifically HIV transmission risk behaviours; (3) delivered by health-care providers or counsellors; (4) delivered to individuals; (5) delivered in an intensive manner; (6) delivered in settings where PLWH receive routine services or medical care; (7) provided skills building, or (8) addressed a myriad of issues related to mental health, medication adherence, and HIV risk behaviour. CONCLUSION: Interventions targeting PWLH are efficacious in reducing unprotected sex and acquisition of sexually transmitted diseases. Efficacious strategies identified in this review should be incorporated into community HIV prevention efforts and further evaluated for effectiveness.

Clinical trial · Confidence interval · Family medicine · Intervention (counseling) · Meta-analysis · Odds ratio · Psychiatry · Psychological intervention · Randomized controlled trial · Adolescent Sexual and Reproductive Health · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Internal Medicine · Medicine

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Unique citing works100
Citations per year5
Citation span2006 - 2024 (19)
Citation velocityrecent
Highly citedNo
Citation typesNeutral: 92

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