Lysergic acid diethylamide (LSD) for alcoholism
Meta-analysis of randomized controlled trials
Bibliographic Data
| ID | 23372003 |
|---|---|
| Authors | Teri S Krebs (Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway), Pål-Ørjan Johansen (Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway) |
| Year | 2012 |
| Volume | 26 |
| Issue | 7 |
| Pages | 994-1002 |
| Publication date | 2012-07-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Psychopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0269-8811 • E-ISSN: 1461-7285 |
| Publisher | SAGE Publications (PUBLISHER • US) |
| DOI | 10.1177/0269881112439253 |
| PMID | 22406913 |
| Language | EN |
| Citations received | 77 |
| References cited | 27 |
Assessments of lysergic acid diethylamide (LSD) in the treatment of alcoholism have not been based on quantitative meta-analysis. Hence, we performed a meta-analysis of randomized controlled trials in order to evaluate the clinical efficacy of LSD in the treatment of alcoholism. Two reviewers independently extracted the data, pooling the effects using odds ratios (ORs) by a generic inverse variance, random effects model. We identified six eligible trials, including 536 participants. There was evidence for a beneficial effect of LSD on alcohol misuse (OR, 1.96; 95% CI, 1.36–2.84; p = 0.0003). Between-trial heterogeneity for the treatment effects was negligible (I 2 = 0%). Secondary outcomes, risk of bias and limitations are discussed. A single dose of LSD, in the context of various alcoholism treatment programs, is associated with a decrease in alcohol misuse.
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| Unique citing works | 77 |
|---|---|
| Citations per year | 5,92 |
| Citation span | 2013 - 2026 (14) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 77 |