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Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976

Bibliographic Data

ID23387388
AuthorsJanet W Rich-Edwards (0000-0001-5066-8808, Brigham and Women's Hospital), Meir J Stampfer (0000-0001-8865-935X, Harvard University), Joann E Manson (0000-0002-9426-7595, General Department of Preventive Medicine), Bernard Rosner, Bernard A Rosner (0000-0001-6907-0056), Susan E Hankinson (0000-0001-9155-3767), Graham A Colditz (0000-0002-7307-0291), Charles H Hennekens (0000-0003-1214-1663), Walter C Willet (Harvard University)
Year1997
Volume315
Issue7105
Pages396-400
Publication date1997-08-16
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueBMJ (JOURNAL)
Journal identifiersISSN: 0007-1447 • E-ISSN: 0267-0623
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/bmj.315.7105.396
PMID9277603
OpenAlexW2042533820
LanguageEN
Citations received67
References cited17

Objective: To examine the association between birth weight and non-fatal adult cardiovascular disease while controlling for potential confounders such as socioeconomic group and adult lifestyle. Design: Retrospective self report of birth weight in an ongoing longitudinal cohort of nurses followed up by postal questionnaire every two years. Setting: Nurses' health study, a cohort of 121 700 women followed up since 1976. Main outcome measures: Non-fatal cardiovascular disease, including myocardial infarction, coronary revascularisation, and stroke. Results: Among the 70 297 women free of cardiovascular disease at baseline who reported birth weight in the 1992 questionnaire there were 1309 first cases of non-fatal cardiovascular disease. Increasing birth weight was associated with decreasing risk of non-fatal cardiovascular disease. There were 1216 first cases of non-fatal cardiovascular disease among women who were singletons and had been born full term; their relative risks adjusted for several cardiovascular risk factors were 1.49 (95% confidence interval 1.05 to 2.10) for birth weight 2495-3175 g (>5 lb 8 oz to 7 lb 0 oz); 1.00 (referent) for birth weight >3175-3856 g (>7 lb 0 oz to 8 lb 8 oz); 0.96 (0.80 to 1.15) for birth weight >3856-4536 g (>8 lb 8 oz to 10 lb 0 oz); and 0.68 (0.46 to 1.00) for birth weight >4536 g (>10 lb 0 oz) (P value for trend=0.0004). The inverse trend was apparent for both coronary heart disease and stroke. Conclusions: These data provide strong evidence of an association between birth weight and adult coronary heart disease and stroke.

Birth weight · Cohort · Cohort study · Confounding · Low birth weight · Myocardial infarction · Obstetrics · Pregnancy · Birth, Development, and Health · Global Health Care Issues · Health disparities and outcomes · Internal Medicine · Medicine · Pediatrics

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Unique citing works67
Citations per year2,39
Citation span1998 - 2022 (25)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 63
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