Infectious disease in the Pleistocene

Old friends or old foes?

Bibliographic Data

ID24314414
AuthorsCharlotte J Houldcroft (0000-0002-1833-5285, Department of Genetics University of Cambridge Downing Street Cambridge UK), Simon Underdown (Human Origins and Palaeoenvironmental Research Group School of Social Sciences, Oxford Brookes University Oxford UK)
Year2023
Volume182
Issue4
Pages513-531
Publication date2023-12-01
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Biological Anthropology (JOURNAL)
Journal identifiersISSN: 2692-7691 • E-ISSN: 2692-7691
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.24737
LanguageEN
Citations received8
References cited214

The impact of endemic and epidemic disease on humans has traditionally been seen as a comparatively recent historical phenomenon associated with the Neolithisation of human groups, an increase in population size led by sedentarism, and increasing contact with domesticated animals as well as species occupying opportunistic symbiotic and ectosymbiotic relationships with humans. The orthodox approach is that Neolithisation created the conditions for increasing population size able to support a reservoir of infectious disease sufficient to act as selective pressure. This orthodoxy is the result of an overly simplistic reliance on skeletal data assuming that no skeletal lesions equated to a healthy individual, underpinned by the assumption that hunter‐gatherer groups were inherently healthy while agricultural groups acted as infectious disease reservoirs. The work of van Blerkom, Am. J. Phys. Anthropol., vol. suppl 37 (2003), Wolfe et al., Nature, vol. 447 (2007) and Houldcroft and Underdown, Am. J. Phys. Anthropol., vol. 160, (2016) has changed this landscape by arguing that humans and pathogens have long been fellow travelers. The package of infectious diseases experienced by our ancient ancestors may not be as dissimilar to modern infectious diseases as was once believed. The importance of DNA, from ancient and modern sources, to the study of the antiquity of infectious disease, and its role as a selective pressure cannot be overstated. Here we consider evidence of ancient epidemic and endemic infectious diseases with inferences from modern and ancient human and hominin DNA, and from circulating and extinct pathogen genomes. We argue that the pandemics of the past are a vital tool to unlock the weapons needed to fight pandemics of the future.