Amplification of DNA Remnants in Mummified Human Brains from Medieval Joseon Tombs of Korea
Bibliographic Data
| ID | 3778309 |
|---|---|
| Authors | Chang Seok Oh (0000-0001-6913-1832, Seoul National University), Sang Jun Lee (0000-0002-2803-753X), Soong Deok Lee (0000-0003-4270-4279), Myeung Ju Kim (0000-0002-7455-5450), Yi‐suk Kim (0000-0003-4793-8875), Yi-Suk Kim, Do-Seon Lim, Dong Hoon Shin (0000-0001-8032-1266) |
| Year | 2013 |
| Volume | 70 |
| Issue | 1 |
| Pages | 57-81 |
| Publication date | 2013-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Anthropologischer Anzeiger (JOURNAL) |
| Journal identifiers | ISSN: 0003-5548 • E-ISSN: 2363-7099 |
| Publisher | S ch we iz er ba rt (PUBLISHER) |
| DOI | 10.1127/0003-5548/2012/0225 |
| PMID | 23590113 |
| OpenAlex | W2319445986 |
| Language | EN |
| Citations received | 3 |
Recently, a number of mummified brains obtained from the remains of medieval Joseon Koreans have been subjected to biological investigations. Although the morphology of the organs had been perfectly maintained on gross examination, we still do not know how well biomolecules such as DNA were preserved. In the present study, the preservation status of remnant DNA in mummified brain tissue was determined by means of comparisons with corresponding DNA taken from the femurs of the same subjects. Quantifiler analysis revealed that DNA from the mummified brain was less fragmented than that contained in the femurs. The better preservation status of the brain DNA was shown also in MiniFiler assays: the number of short tandem repeat (STR) locus profiles for the mummified brain was far higher than in the case of the femur bones. In the case of the mtDNA analysis, longer DNA fragments (821 bp) could be successfully amplified with brain samples, whereas only shorter PCR amplicons (221-263 bp) were seen with the femur samples. Indeed mummified brain tissue, if discovered in amounts suitable for ancient DNA analysis, promises to be the preferred source for genetic analysis of individuals from pre-modern Korean tombs.
Amplicon · Ancient DNA · Biology · DNA · Evolutionary biology · Gene · Microsatellite · Mitochondrial DNA · Nuclear DNA · Polymerase chain reaction · STR analysis · Forensic and Genetic Research · Forensic Anthropology and Bioarchaeology Studies · Genetics · Medicine · Paleopathology and ancient diseases
Tracing the historical origin of Joseon mummies considering the structural similarities between the burial systems of Korean and Chinese dynasties
Single-nucleotide polymorphism analyses on ABCC11, Edar, FGFR2, and ABO genotypes of mummified people of the Joseon Dynasty, South Korea
Multiplex Ligation Dependent Probe Amplification (MLPA) Assay on Joseon Mummified Samples from Archaeological Sites of South Korea
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,27 |
| Citation span | 2015 - 2018 (4) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |