Genetic underpinnings of risky behaviour relate to altered neuroanatomy
Bibliographic Data
| ID | 4636864 |
|---|---|
| Authors | Gökhan Aydogan (0000-0003-2187-7912, University of Zurich), Remi Daviet (0000-0003-0838-3619, University of Pennsylvania), Richard Karlsson Linnér (0000-0001-7839-2858, Vrije Universiteit Amsterdam), Todd A Hare (0000-0002-0260-2772, University of Zurich), Joseph W Kable (0000-0001-6495-9040, University of Pennsylvania), Henry R Kranzler (0000-0002-1018-0450, Veterans Health Administration), Reagan R Wetherill (0000-0002-1991-6292, University of Pennsylvania), Christian C Ruff (0000-0002-3964-2364, University of Zurich), Philipp D Koellinger (0000-0001-7413-0412, University of Wisconsin–Madison), Gideon Nave (0000-0001-6251-5630, William P. Wharton Trust, corresponding author), Big Bear Consortium |
| Year | 2021 |
| Volume | 5 |
| Issue | 6 |
| Pages | 787-794 |
| Publication date | 2021-01-28 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Nature Human Behaviour (JOURNAL) |
| Journal identifiers | ISSN: 2397-3374 • E-ISSN: 2397-3374 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/s41562-020-01027-y |
| PMID | 33510390 |
| OpenAlex | W3125511329 |
| Language | EN |
| Citations received | 4 |
| References cited | 47 |
Previous research points to the heritability of risk-taking behaviour. However, evidence on how genetic dispositions are translated into risky behaviour is scarce. Here, we report a genetically informed neuroimaging study of real-world risky behaviour across the domains of drinking, smoking, driving and sexual behaviour in a European sample from the UK Biobank (N = 12,675). We find negative associations between risky behaviour and grey-matter volume in distinct brain regions, including amygdala, ventral striatum, hypothalamus and dorsolateral prefrontal cortex (dlPFC). These effects are replicated in an independent sample recruited from the same population (N = 13,004). Polygenic risk scores for risky behaviour, derived from a genome-wide association study in an independent sample (N = 297,025), are inversely associated with grey-matter volume in dlPFC, putamen and hypothalamus. This relation mediates roughly 2.2% of the association between genes and behaviour. Our results highlight distinct heritable neuroanatomical features as manifestations of the genetic propensity for risk taking
Amygdala · Biobank · Biology · Cognition · Dorsolateral prefrontal cortex · Environmental health · Gene · Genetic association · Genome-wide association study · Grey matter · Heritability · Neuroanatomy · Neuroimaging · Population · Prefrontal cortex · Putamen · Single-nucleotide polymorphism · Striatum · Ventral striatum · White matter · Behavioral Health and Interventions · Cognitive Abilities and Testing · Genetic Associations and Epidemiology · Medicine · Neuroscience · Psychology · Genetics
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| Unique citing works | 4 |
|---|---|
| Citations per year | 1 |
| Citation span | 2022 - 2025 (4) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 4 |