The positive association between serum uric acid, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus in the Elsa-Brasil study

Bibliographic Data

ID5166684
AuthorsAline Isabel Rodrigues Galvão (0000-0002-1405-3897, Universidade Federal de Minas Gerais), Alline Maria R Beleigoli (0000-0002-7848-3183, Flinders University), Pedro G Vidigal (0000-0001-8035-1350, Universidade Federal de Minas Gerais), Bruce B Duncan (0000-0002-7491-2630, Universidade Federal do Rio Grande do Sul), Maria Ines Schmidt (0000-0002-3837-0731, Universidade Federal do Rio Grande do Sul), Sarah L Appleton (0000-0001-7292-9714, The University of Adelaide), Sandhi Maria Barreto (0000-0001-7383-7811, Universidade Federal de Minas Gerais), Maria De Fátima Haueisen Sander Diniz (0000-0001-9146-5003, Universidade Federal de Minas Gerais)
Year2021
Volume37
Issue9
Pagese00255920-e00255920
Publication date2021-01-01
Open AccessYes
TypeARTICLE
VenueCadernos de Saude Publica (JOURNAL)
Journal identifiersISSN: 0102-311X • E-ISSN: 1678-4464
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/0102-311x00255920
PMID34669776
OpenAlexW3207705966
SciELOS0102-311X2021000905010
LanguageEN
References cited28

There is a conflict in the literature regarding the association between serum uric acid (SUA) levels and glycemic status. Therefore, we evaluated the association between SUA level and glycemic status - impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus - and insulin resistance, in a large Brazilian study. This is a cross-sectional, observational study with 13,207 participants aged 35-74 years, at baseline (2008-2010) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). A multinomial regression analysis was performed to test the association between SUA and glycemic status (IFG, IGT, and newly diagnosed type 2 diabetes at the cohort baseline) after adjustments by age, sex, skin color, body mass index, physical activity, smoking, alcohol consumption, comorbidities, and medicines use. Logistic regression model was used to evaluate the association between SUA and insulin resistance by HOMA-IR. Stratified analyses by sex were performed. The mean age (standard deviation) was 51.4 (8.9) years, 55.2% of participants were women. There were 1,439 newly diagnosed diabetes. After all adjustments, higher SUA was associated with IFG, IGT, and diabetes, with odds ratio (OR) = 1.15 (95%CI: 1.06; 1.25), 1.23 (95%CI: 1.14; 1.33), and 1.37 (95%CI: 1.24; 1.51), respectively. There was association between SUA levels and insulin resistance with OR = 1.24 (95%CI: 1.13; 1.36). In analysis stratified by sex, higher SUA persisted independently associated with impaired glycemic status. Our results suggest that a higher SUA levels were significantly associated with glycemic status in a large Latin American population, mainly among women

Body mass index · Diabetes mellitus · Glycemic · Impaired fasting glucose · Impaired glucose tolerance · Insulin resistance · Odds ratio · Type 2 diabetes · Alcohol Consumption and Health Effects · Endocrinology · Gout, Hyperuricemia, Uric Acid · Inflammasome and immune disorders · Internal Medicine · Medicine

Tools

Open DOIOpen Access