Antiobesity effect and metabolite analysis of catechin functional kimchi
Bibliographic Data
| ID | 5167344 |
|---|---|
| Authors | Geun-Hye Hong (0000-0001-6571-1100, LG (South Korea), corresponding author), So-Young Lee (0000-0003-0457-3167), So‐Young Lee (0000-0002-5020-5982, LG (South Korea)), Kun-Young Park (0000-0002-2674-0715), Kun‐Young Park (LG (South Korea)) |
| Year | 2024 |
| Volume | 11 |
| Issue | 1 |
| Publication date | 2024-09-26 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnic Foods (JOURNAL) |
| Journal identifiers | ISSN: 2352-6181 • E-ISSN: 2352-619X |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1186/s42779-024-00248-0 |
| OpenAlex | W4402841471 |
| Language | EN |
| References cited | 49 |
The antiobesity effects of catechin functional kimchi (CFK) were studied in C57BL/6 mice with high-fat diet (HFD)-induced obesity. We prepared four types of kimchi: commercial kimchi (CK), standard kimchi (SK), green tea functional kimchi (GFK), and CFK. CFK decreased the adipo-/lipogenesis-related genes of CCAAT/enhancer binding protein α (C/EBPα), peroxisome proliferator-activated receptor-γ (PPARγ), and sterol regulatory element-binding protein-1 (SREBP-1) in the liver and epididymal tissues (p < 0.05). On the other hand, CFK showed the highest lipolysis-related gene expression of hormone-sensitive lipase (HSL) and β-oxidation related gene expression of carnitine palmitoyltransferase 1 (CPT-1). CFK produced the lowest inflammation-related mRNA expression of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) among all groups in the epididymal tissues (p < 0.05). In addition, UPLC-Q-TOF-MS showed that CFK is composed mainly of 39 active compounds, e.g., epigallocatechin gallate (EGCG), catechins, apigenin, myricetin, kaempferitin, rutin, quercetin, and other substances with anti-inflammatory, blood cholesterol reduction, blood sugar reduction, body fat reduction, antioxidant, and anticancer functions. Thus, CFK exhibited an antiobesity effect through its modulation of lipid metabolism and active compounds
Catechin · Metabolite · Polyphenol · Traditional medicine · Chemistry · Food Quality and Safety Studies · Medicine · Phytochemicals and Antioxidant Activities · Phytoestrogen effects and research · Biochemistry · Food Science
| Citation velocity | historical |
|---|---|
| Highly cited | No |