Antiobesity effects of kimchi in diet-induced obese mice
Bibliographic Data
| ID | 5166000 |
|---|---|
| Authors | Meizi Cui (Pusan National University), Hee-Young Kim (0000-0002-2637-8621, Pusan National University), Kyung Hee Lee (0000-0001-5849-7820, Pusan National University), Ji-Kang Jeong, Ji‐Kang Jeong (Pusan National University), Ji-Hee Hwang, Kyu-Young Yeo, Byung-Hee Ryu, Jung-Ho Choi, Kun-Young Park (0000-0002-2674-0715), Kun‐Young Park (Pusan National University, corresponding author) |
| Year | 2015 |
| Volume | 2 |
| Issue | 3 |
| Pages | 137-144 |
| Publication date | 2015-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnic Foods (JOURNAL) |
| Journal identifiers | ISSN: 2352-6181 • E-ISSN: 2352-619X |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1016/j.jef.2015.08.001 |
| OpenAlex | W2152581759 |
| Language | EN |
| Citations received | 4 |
| References cited | 28 |
The present study was investigated to confirm the antiobesity effect of kimchi in high-fat diet-induced obese C57BL/6 mice. Mice in the high-fat diet (HFD) group, standardized kimchi (S-Kimchi) group, and Korean commercial kimchi (D-Kimchi) group, but not in the normal-diet group, were fed a high-fat diet (HFD) for the first 4 weeks to induce obesity. From the 5th to 8th weeks, the S- and D-Kimchi groups were fed an HFD containing 10% of S-Kimchi or D-Kimchi, respectively. After 8 weeks, mice were sacrificed and obesity-related factors were determined. Body and adipose tissue weights were significantly lower in the kimchi-treated groups than in the HFD group. In particular, in the D-Kimchi group, serum levels of triglyceride, total cholesterol, low-density lipoprotein-cholesterol, insulin, and leptin were significantly lower, and serum levels of high-density lipoprotein-cholesterol and adiponectin were markedly higher than those in the HFD group. Moreover, hepatic mRNA expression of adipogenesis-related genes (CCAAT/enhance-binding protein-α, peroxisome proliferator-activated receptor-γ, sterol regulatory element-binding protein-1c, and fatty acid synthase) in the kimchi-treated groups were lower than those in the HFD group, but fatty acid oxidation-related carnitine palmitoyltransferase-1 expressions were higher. In addition, kimchi decreased the mRNA levels of the inflammation-related monocyte chemotactic protein-1 and interleukin-6 in epididymal fat tissue. Administration of kimchi, especially of D-Kimchi, which contained Leuconostoc mesenteroides DRC 0211 starter and other subingredients, exhibited antiobesity activity by reducing body weight gains and adipose tissue weights; modulating serum lipid profiles and hepatic lipogenesis; regulating serum insulin, leptin, and adiponectin levels; and reducing adipocyte size and inflammatory response in epididymal fat tissues
Adiponectin · Adipose tissue · Biology · Carnitine · Cholesterol · Fatty acid synthase · Insulin resistance · Leptin · Lipid metabolism · Obesity · Triglyceride · Chemistry · Food Quality and Safety Studies · Medicine · Phytoestrogen effects and research · Tea Polyphenols and Effects · Endocrinology · Internal Medicine
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| Unique citing works | 4 |
|---|---|
| Citations per year | 0,44 |
| Citation span | 2017 - 2024 (8) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 4 |