Liver steatosis as a predictor of incident diabetes in adults

A prospective evaluation in the Brazilian Longitudinal Study of Adult Health (Elsa-Brasil)

Bibliographic Data

ID5167398
AuthorsLuciana Costa Faria (0000-0002-0226-3491, Universidade Federal de Minas Gerais), Maria De Fátima Haueisen Sander Diniz (0000-0001-9146-5003, Universidade Federal de Minas Gerais), Luana Giatti (0000-0001-5454-2460, Hospital das Clínicas da Universidade Federal de Minas Gerais), Maria Ines Schmidt (0000-0002-3837-0731, Universidade Federal do Rio Grande do Sul), Ana Caroline Goulart (0000-0003-1076-5210, Universidade de São Paulo), Bruce B Duncan (0000-0002-7491-2630, Universidade Federal do Rio Grande do Sul), Sandhi Maria Barreto (0000-0001-7383-7811, Hospital das Clínicas da Universidade Federal de Minas Gerais)
Year2023
Volume39
Issue3
Pagese00090522-e00090522
Publication date2023-01-01
Open AccessYes
TypeARTICLE
VenueCadernos de Saude Publica (JOURNAL)
Journal identifiersISSN: 0102-311X • E-ISSN: 1678-4464
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/0102-311xen090522
PMID37477601
OpenAlexW4362499355
SciELOS0102-311X2023000305005
LanguageEN
Citations received1
References cited32

Increasing epidemiological evidence suggests a bidirectional relationship between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and that NAFLD may precede and/or promote the development of diabetes. This study aimed to investigate whether liver steatosis is associated with the incidence of diabetes in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The ELSA-Brasil is an occupational cohort study of active or retired civil servants, aged 35-74 years, in six capital cities in Brazil. We excluded participants with diabetes at baseline, those who reported excessive alcohol consumption or with missing information on relevant covariates, and those with self-referred hepatitis or cirrhosis. In total, 8,166 individuals participated, and the mean duration of follow-up was 3.8 years. The Cox proportional regression model was used to estimate the adjusted hazard ratio (HR) for the associations. Abdominal ultrasonography was used to detect liver steatosis. In the follow-up period, the cumulative incidence of diabetes was 5.25% in the whole sample, 7.83% and 3.88% in the groups with and without hepatic steatosis, respectively (p < 0.001). Compared to those without steatosis, individuals with hepatic steatosis had an increased risk of developing diabetes (HR = 1.31; 95%CI: 1.09-1.56) after adjustment for potential confounders, including body mass index (BMI). Hepatic steatosis was an independent predictor of incident diabetes in the ELSA-Brasil cohort study. Physicians should encourage changes in lifestyle and screen for diabetes in patients with fatty liver

Body mass index · Cirrhosis · Cohort · Cohort study · Confidence interval · Confounding · Diabetes mellitus · Disease · Fatty liver · Hazard ratio · Incidence (geometry) · Longitudinal study · Pathology · Proportional hazards model · Prospective cohort study · Steatosis · Type 2 diabetes · Alcohol Consumption and Health Effects · Diet, Metabolism, and Disease · Endocrinology · Epidemiology · Internal Medicine · Liver Disease Diagnosis and Treatment · Medicine

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Open DOIOpen Access