Fresh or Thawed T Cells
How Modes of Bioavailability Matter in the Study of Translational Medicine
Bibliographic Data
| ID | 5362089 |
|---|---|
| Authors | Violeta Argudo-Portal (0000-0002-6057-2559, Universitat de Barcelona, corresponding author) |
| Year | 2025 |
| Volume | 50 |
| Issue | 2 |
| Pages | 274-298 |
| Publication date | 2025-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Science Technology & Human Values (JOURNAL) |
| Journal identifiers | ISSN: 0162-2439 • E-ISSN: 1552-8251 |
| Publisher | SAGE Publications Inc (PUBLISHER) |
| DOI | 10.1177/01622439231171972 |
| OpenAlex | W4379011622 |
| Language | EN |
| Citations received | 4 |
| References cited | 35 |
This article explores how cell immunotherapy becomes deliverable at the in-betweens of the bench, bedside, and community in translational medicine. During ethnographic research in an advanced cell therapies unit, I observed how the staff made virus-specific T cells available for therapeutic use. In dialogue with recent Science and Technology Studies scholars' thinking around the concept of readiness, this paper highlights the analytic richness of paying empirical attention to how biological therapeutics are made available (i.e., their modes of bioavailability ). This study identifies two modes of bioavailability for landing cellular drugs at the bedside. In bioavailability mode I, cells are banked in potential donors' bodies and extracted for fresh infusion. In bioavailability mode II, cells are expanded and cryobanked in a cell bank for thawed infusion. Each mode offers different degrees of readiness and matching. I argue that ethnographic analysis of modes of bioavailability in health innovation and therapeutics implementation enables a less finalist and mass production understanding of translational medicine. This work highlights the relevance of exploring the practices, logistics, and logics that make some modes of bioavailability more valuable than others in pharmaceutical terms-and biomedicine more broadly
Bioavailability · Bioinformatics · Biology · Biomedicine · Knowledge management · Biomedical and Engineering Education · Biomedical Ethics and Regulation · CAR-T cell therapy research · Computer Science · Medicine · Pharmacology
The invention of modern science
Operability, Bioavailability, and Exception
Repairing the ‘Broken Middle’ of the Health Innovation Pathway
‘The Biopolitics of Postmodern Bodies
Beyond the ‘therapeutic misconception’
The rare and the common
Bench, bedside, boardroom
From Bedside to Bench? Communities of Promise, Translational Research and the Making of Blood Stem Cells
Translational neonatology research
Controlled human malaria infection trials
Extending the rails
Enacting the ‘neuro’ in practice
Microbial Extractions
Platform NHS
Welcome to Whenever
Ready for What
Theorizing the Bioeconomy
Accelerating Innovation in the Creation of Biovalue
The social management of biomedical novelty
Temporality and Prudence
Promissory identities
Some Elements of a Sociology of Translation
Innovative Health Technologies and the Social
The Legacies of Writing Culture and the Near Future of the Ethnographic Form
Nonself Help
| Unique citing works | 4 |
|---|---|
| Citations per year | 2 |
| Citation span | 2024 - 2026 (3) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 3 |