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The origin and antiquity of syphilis revisited

An Appraisal of Old World pre-Columbian evidence for treponemal infection

Bibliographic Data

ID5820607
AuthorsKristin N Harper (0000-0002-5181-1263, corresponding author), Molly K Zuckerman, Megan L Harper, John D Kingston (0000-0001-7859-8696), George J Armelagos
Year2011
Volume146
IssueS53
Pages99-133
Publication date2011-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.21613
PMID22101689
OpenAlexW1999741569
LanguageEN
Citations received61
References cited138

For nearly 500 years, scholars have argued about the origin and antiquity of syphilis. Did Columbus bring the disease from the New World to the Old World? Or did syphilis exist in the Old World before 1493? Here, we evaluate all 54 published reports of pre-Columbian, Old World treponemal disease using a standardized, systematic approach. The certainty of diagnosis and dating of each case is considered, and novel information pertinent to the dating of these cases, including radiocarbon dates, is presented. Among the reports, we did not find a single case of Old World treponemal disease that has both a certain diagnosis and a secure pre-Columbian date. We also demonstrate that many of the reports use nonspecific indicators to diagnose treponemal disease, do not provide adequate information about the methods used to date specimens, and do not include high-quality photographs of the lesions of interest. Thus, despite an increasing number of published reports of pre-Columbian treponemal infection, it appears that solid evidence supporting an Old World origin for the disease remains absent. Yrbk Phys Anthropol 54:99-133, 2011. (c) 2011 Wiley Periodicals, Inc

Critical appraisal · Old World · Forensic Anthropology and Bioarchaeology Studies · Race, Genetics, and Society · Syphilis Diagnosis and Treatment

  • First Peoples in a New World

    D J Meltzer•First Peoples in a New World•2021

  • The Science Behind Pre‐Columbian Evidence of Syphilis in Europe

    Open Access•George J Armelagos, M K Zuckerman et al.•Evolutionary Anthropology Issues…•2012

  • Two Probable Cases of Infection with Treponema pallidum during the Neolithic Period in Northern Vietnam (ca. 2000–1500 B.C.)

    M Vlok, Marc F Oxenham et al.•Bioarchaeology International•2020

  • Patterns of Disease and Culture in Ancient Panama

    Nicole E Smith-Guzm ́an, Nicole Smith-Guzmán et al.•Bioarchaeology International•2021

  • Diagnosis and evaluation of causative factors for the presence of endemic treponemal disease in a Japanese sub-tropical island population from the Tokugawa period

    Open Access•Mauricio Hernández, M Hudson et al.•International Journal of…•2015

  • Treponemal infection in Peru's Early Colonial period

    Open Access•Haagen D Klaus, Donald J Ortner•International Journal of…•2014

  • A paleoepidemiological approach to the challenging differential diagnosis of an isolated 1500-year-old anomalous molar from Panamá

    Open Access•Nicole E Smith-Guzm ́an•International Journal of…•2022

  • A content analysis by bibliometry of the first ten years of the International Journal of Paleopathology

    Open Access•S A Mays•International Journal of…•2021

  • Dental developmental defects in a subadult from 16th–19th centuries Bucharest, Romania

    Open Access•Claudia Florina Radu, A Soficaru et al.•International Journal of…•2016

  • Treponematosis in a pre-Columbian hunter-gatherer male from Antofagasta (1830 ± 20 BP, Northern Coast of Chile)

    Open Access•Mario Castro, Aryel Pacheco et al.•International Journal of…•2020

  • Syphilis in an Italian medieval jewish community

    Open Access•A Pietrobelli, Mariotti et al.•International Journal of…•2020

  • Paleopathological rigor and differential diagnosis

    Open Access•Haagen D Klaus•International Journal of…•2017

  • An isotopic case study of individuals with syphilis from the pathological-anatomical reference collection of the national museum in Prague (Czech Republic, 19th century A.D.)

    Open Access•Kevin Salesse, Sylva Kaupová et al.•International Journal of…•2019

  • The madness they endured

    Open Access•Madeline M Atwell•International Journal of…•2022

  • How should we diagnose disease in palaeopathology? Some epistemological considerations

    Open Access•May, Simon Mays•International Journal of…•2018

  • A probable case of congenital syphilis from 18th century Vienna

    Open Access•Johanna Sophia Gaul, Karl Grossschmidt•International Journal of…•2014

  • Human migration, infectious diseases, plague, global health crisis - historical evidence

    Open Access•Sri Endah Kinasih, Shrimarti Rukmini Devy et al.•Cogent Arts and Humanities•2024

  • A case of syphilis in Gustav Klimt’s Medicine? Iconodiagnosis and historical review

    Open Access•O Simonetti, Antonio Perciaccante et al.•Ethics Medicine and Public Health•2026

  • L’origine de la syphilis

    Open Access•O Dutour•Les Nouvelles de l archéologie•2022

  • Antisyphilitic Mercury Drugs in Early Modern China and Japan

    Daniel Trambaiolo•Asiatische Studien – Études…•2015

  • Differential sampling for genetic analyses of Treponema pallidum and for radiocarbon dating in archaeological bone

    Open Access•Karen Giffin, Ariane Weber et al.•International Journal of…•2025

  • Congenital syphilis in the skeleton of a child from Poland (Radom, 18th–19th century AD)

    Open Access•J Tomczyk, Hanna Mańkowska-Pliszka et al.•Anthropological Review•2015

  • Dental signs attributed to congenital syphilis and its treatments in the Hamann-Todd Skeletal Collection

    Open Access•Stella Ioannou, M Henneberg•Anthropological Review•2017

  • Biocultural perspectives of infectious diseases and demographic evolution

    Open Access•T P Van Doren•Evolutionary Anthropology Issues…•2023

  • New World, New Germs

    Josephine Benson•Terrae Incognitae•2015

  • A case of bilateral cleft palate with obturator prosthesis from XVIII century Cracow (Poland)

    Open Access•A E Spinek, Marta Kurek et al.•Journal of Archaeological Science…•2023

  • More Harm than Healing? Investigating the Iatrogenic Effects of Mercury Treatment on Acquired Syphilis in Post-medieval London

    Open Access•M K Zuckerman•Open Archaeology•2016

  • Oozing Ulcer

    Open Access•Jens Heimdahl, Maria Vretemark•International Journal of…•2017

  • The Osteological Paradox 20 Years Later

    Open Access•N Dewitte, C M Stojanowski•Journal of Archaeological Research•2015

  • Multiple Cases with Probable Treponemal Infection from 16th to 19th Centuries Romania

    Open Access•C Radu, Claudia Florina Radu et al.•International Journal of…•2015

  • Dental Stigmata and Skeletal Lesions of Congenital Treponematosis in Early Agricultural Vietnam (4000–3500 bp )

    Open Access•M Vlok, Tran Thi Minh et al.•International Journal of…•2026

  • Applying the Index of Care to the Mississippian period

    Open Access•M K Zuckerman, Kelly R Kamnikar et al.•International Journal of…•2019

  • Infectious diseases and Neolithic transformations

    Open Access•Katharina Fuchs, Christoph Rinne et al.•The Holocene•2019

  • Treponematosis in Pre-Columbian Jamaica

    Open Access•Ana Luisa Santos, Michael Gardner et al.•Journal of Archaeological Science•2012

  • La sífilis y su carácter endémico en la ciudad de México

    Open Access•Lourdes Márquez Morfín, Lourdes Márquez-Morfín•Historia Mexicana•2015

  • Death in the sun

    E Pomeroy, Jennifer Grant et al.•Post-Medieval Archaeology•2018

  • The All Saints Anchoress? An Osteobiography

    Lauren McIntyre, Lauren Kancle et al.•Medieval Archaeology•2022

  • Syphilis revisited

    Open Access•G Cole, H A Waldron•American Journal of Physical…•2012

  • Genomics, the origins of agriculture, and our changing microbe‐scape

    Open Access•Kristin N Harper, George J Armelagos•American Journal of Physical…•2013

  • Response to Cole and Waldron's “letter to the editor

    Open Access•Molly K Zuckerman, Kristin N Harper et al.•American Journal of Physical…•2012

  • Advancing the understanding of treponemal disease in the past and present

    Open Access•Brenda J Baker, Gillian Crane‐kramer et al.•American Journal of Physical…•2020

  • Isotopic tracing of the impact of mobility on infectious disease

    Open Access•Charlotte A Roberts, Andrew R Millard et al.•American Journal of Physical…•2013

  • Evidence of skeletal treponematosis from the medieval burial ground of S t. M ary S pital, L ondon, and implications for the origins of the disease in E urope

    Open Access•Don D Walker, Don Walker et al.•American Journal of Physical…•2015

  • Bioarchaeology in the ancient N ear E ast

    Open Access•Susan Guise Sheridan•American Journal of Physical…•2017

  • Infectious Disease and the Diversification of the Human Genome

    J F Brinkworth, Jessica F Brinkworth Jessica F Brinkworth•Human Biology•2017

  • Paleopathological Studies of Infectious Disease

    Open Access•E J Woo, Jae-Hyun Kim et al.•Korean Journal of Physical…•2018

  • Syphilitic infection in a pre-modern population from South Korea (19th century AD)

    Open Access•E J Woo, Jae-Hyun Kim et al.•Anthropological Science•2019

  • Treponemal disease in the Old World? Integrated palaeopathological assessment of a 9th–11th century skeleton from north-central Spain

    Open Access•Belen Lopez, José Manuel Lopez-Garcia et al.•Anthropological Science•2017

  • The "Poxed" and the "Pure

    Open Access•M K Zuckerman•Archeological Papers of the…•2017

  • Treponematoses e outras paleopatologias em sítios arqueológicos pré-históricos do litoral sul e sudeste do Brasil

    Open Access•José Filippini•2012

  • Ancient pathogen genomics

    Open Access•Kelly M Harkins, Anne C Stone•Journal of Human Evolution•2015

  • Renaissance mercurial therapy in the mummies of Saint Domenico Maggiore in Naples

    Open Access•A Fornaciari, Silvio Chericoni et al.•Archaeological and Anthropological…•2022

  • A brief history of syphilis in the Czech Lands

    Open Access•Lenka Vargová, Kateřina Vymazalová et al.•Archaeological and Anthropological…•2019

  • A possible case of acquired syphilis at the former Royal Hospital of All-Saints (RHAS) in Lisbon, Portugal (18th century)

    Sandra Assi, Sandra Assis et al.•Anthropologischer Anzeiger•2015

  • Adapt or Die

    Open Access•M K Zuckerman, Kristin N Harper et al.•International Journal of…•2016

  • Hypomineralization disorder in tropical Southeast Asia during the agricultural revolution

    Open Access•M Vlok, Marc F Oxenham et al.•International Journal of…•2024

  • Volcanoes, medicine, and monasticism

    Open Access•J W Walser, Steinunn Kristjánsdóttir et al.•International Journal of…•2019

  • Impact of Infectious Disease on Humans and Our Origins

    Open Access•Petar Gabrić•Anthropological Review•2022

  • The Bioarchaeology of Health Crisis

    Clark Spencer Larsen•Annual Review of Anthropology•2018

  • George John Armelagos (1936-2014)

    Open Access•Alan H Goodman, Alan C Swedlund et al.•American Anthropologist•2015

  • Finding Archaeological Relevance during a Pandemic and What Comes After

    Open Access•Lynn H Gamble, Cheryl Claassen et al.•American Antiquity•2021

  • Syphilis 2001 a palaeopathological reappraisal

    Open Access•C Meyer, C Jung et al.•HOMO•2002

  • Archaeology of Ancient Australia

    Peter Hiscock•Archaeology of Ancient Australia•2007

  • The Archaeology of Human Bones

    May, Simon Mays•Archaeology of Human Bones•2002

  • Health and Welfare during Industrialization

    Richard H Steckel, Roderick Floud•Health and Welfare During…•1997

  • Bioarchaeology

    Open Access•Clark Spencer Larsen•Bioarchaeology•1997

  • Diagnostic Criteria of Syphilis, Yaws and Treponarid (Treponematoses) and of Some Other Diseases in Dry Bones

    Open Access•C J Hackett, C J Hacket•Diagnostic Criteria of Syphilis,…•1976

  • Palaeopathology of Aboriginal Australians

    Open Access•Stephen Webb, Stephen G Webb•Palaeopathology of Aboriginal…•1995

  • Methodological approaches to determining the marine radiocarbon reservoir effect

    Open Access•Philippa Ascough, Gordon Cook et al.•Progress in Physical Geography:…•2005

  • Identification of pathological conditions in human skeletal remains

    Open Access•Donald J Ortner, Walter G J Putschar•Smithsonian contributions to…•1985

  • Stable isotope evidence for increasing dietary breadth in the European mid-Upper Paleolithic

    Open Access•Michael P Richards, Michael Richards et al.•Proceedings of the National…•2001

  • Stable Nitrogen Isotope Ratios of Bone Collagen Reflect Marine and Terrestrial Components of Prehistoric Human Diet

    Open Access•Margaret J Schoeninger, Michael J Deniro et al.•Science•1983

  • Revised direct radiocarbon dating of the Vindija G 1 Upper Paleolithic Neandertals

    Open Access•T F G Higham, Tom Higham et al.•Proceedings of the National…•2006

  • Nitrogen and carbon isotopic composition of bone collagen from marine and terrestrial animals

    Open Access•Margaret J Schoeninger, Michael J Deniro•Geochimica et Cosmochimica Acta•1984

  • Formation processes of the archaeological record

    Michael B Schiffer•Formation processes of the…•1987

  • Congenital Syphilis in the Archaeological Record

    Open Access•Bruce M Rothschild, Bruce Rothschild et al.•International Journal of…•1997

  • St Trolla's Chapel, Kintradwell, Sutherland

    Open Access•Olivia Lelong, Julie Roberts et al.•Scottish Archaeological Journal•2003

  • Probable Treponematosis in Human Skeletons from the Himrin Basin of Iraq

    Open Access•Yo Wada, Jiro Ikeda et al.•The Journal of Anthropological…•1987

  • Subadult stress, morbidity, and longevity in Latte Period populations on Guam, Mariana Islands

    Open Access•Ann L W Stodder•American Journal of Physical…•1997

  • An assessment of health and disease in the prehistoric inhabitants of the Mariana Islands

    Open Access•M Pietrusewsky, Michele Toomay Douglas et al.•American Journal of Physical…•1997

  • Paleohistopathology of bone

    Open Access•Michael Schultz•American Journal of Physical…•2001

  • A Review of Current Approaches in the Pretreatment of Bone for Radiocarbon Dating by AMS

    Open Access•R E M Hedges, G J VAN KLINKEN•Radiocarbon•1992

  • Bioarchaeology

    Open Access•Clark Spencer Larsen•Journal of Archaeological Research•2002

  • Stable isotope variation in pathological bone

    Open Access•M Anne Katzenberg, Nancy C Lovell•International Journal of…•1999

  • Medieval examples of syphilis from European Russia

    Open Access•A P Buzhilova, Alexandra Buzhilova•International Journal of…•1999

  • Treponematosis in Pre‐Spanish Western Micronesia

    Open Access•Diane L Trembly•International Journal of…•1996

  • Analysis of treponemal disease in North Africa

    Open Access•Bruce Rothschild, B M Rothschild et al.•Human Evolution•1996

  • Evaluation of radiocarbon dates from the Middle Holocene hunter-gatherer cemetery Khuzhir-Nuge XIV, Lake Baikal, Siberia

    Open Access•A W Weber, Andrzej Weber et al.•Journal of Archaeological Science•2005

  • Fast or feast

    Open Access•Gundula Müldner, Michael Richards•Journal of Archaeological Science•2004

  • Stable isotopes in human skeletons of Southern Ontario

    Open Access•H P Schwarcz, Jerry Melbye et al.•Journal of Archaeological Science•1985

  • Ancient Maya diet

    Open Access•Christine D White, H P Schwarcz•Journal of Archaeological Science•1989

  • Stable Isotope Evidence for Similarities in the Types of Marine Foods Used by Late Mesolithic Humans at Sites Along the Atlantic Coast of Europe

    Open Access•Michael Richards, M P Richards et al.•Journal of Archaeological Science•1999

  • The radiocarbon reservoir effect

    Open Access•Malcolm Lillie, Chelsea Budd et al.•Journal of Archaeological Science•2008

  • Stable hydrogen isotopes of bone collagen in palaeodietary and palaeoenvironmental reconstruction

    Open Access•Linda M Reynard, R E M Hedges•Journal of Archaeological Science•2008

  • Radiocarbon dating and the “old wood” problem

    Open Access•Michael Brian Schiffer•Journal of Archaeological Science•1986

  • Radiocarbon Marine Reservoir Effect in Human Remains from the Kitakogane Site, Hokkaido, Japan

    Open Access•Minoru Yoneda, Atsushi Tanaka et al.•Journal of Archaeological Science•2002

  • The potential significance of dietary offsets for the interpretation of radiocarbon dates

    Open Access•Alex Bayli, A Bayliss et al.•Journal of Archaeological Science•2003

  • Marine diets in the European late Upper Paleolithic

    Open Access•Michael Richards, M P Richards et al.•Journal of Human Evolution•2006

  • Isotopes and red herrings

    Open Access•R E M Hedges•Antiquity•2004

  • Change of Diet of the Greenland Vikings Determined from Stable Carbon Isotope Analysis and 14 C Dating of Their Bones

    Open Access•Jette Arneborg, Jan Heinemeier et al.•Radiocarbon•1999

  • A Freshwater Diet-Derived 14 C Reservoir Effect at the Stone Age Sites in the Iron Gates Gorge

    Open Access•G T Cook, C Bonsall et al.•Radiocarbon•2001

  • Validating and Improving Archaeological Phasing at St. Mary Spital, London

    Open Access•Jane Sidell, Christopher Thomas et al.•Radiocarbon•2007

  • Histological identification of syphilis in pre‐Columbian England

    Open Access•Tanya E von Hunnius, Charlotte A Roberts et al.•American Journal of Physical…•2006

  • Technical note

    Open Access•P D Mitchell•American Journal of Physical…•2009

  • Investigating the specificity of periosteal reactions in pathology museum specimens

    Open Access•Darlene A Weston•American Journal of Physical…•2008

  • The developmental genetics and evolutionary meaning of the metopic suture

    Open Access•Johan Torgersen•American Journal of Physical…•1951

  • Congenital syphilis in the past

    Open Access•Keith P Jacobi, Della Collins Cook et al.•American Journal of Physical…•1992

  • Deciduous dental morphology and the biological affinities of a late Chalcolithic skeletal series from western India

    Open Access•J R Lukacs, Subhash R Walimbe•American Journal of Physical…•1984

  • Two probable cases of treponemal disease of Medieval date from England

    Open Access•May, Simon Mays et al.•American Journal of Physical…•2003

  • Pre‐Columbian treponemal disease from 14th century AD Safed, Israel, and implications for the medieval eastern Mediterranean

    Open Access•P D Mitchell•American Journal of Physical…•2003

  • Regional, social, and evolutionary perspectives on treponemal infection in the Southeastern United States

    Open Access•Dale L Hutchinson, Rebecca Richman•American Journal of Physical…•2006

  • Apple Down 152

    Open Access•G Cole, Tony Waldron•American Journal of Physical…•2011

  • Stable isotope evidence for 1500 years of human diet at the city of York, UK

    Open Access•Gundula Müldner, Michael P Richards et al.•American Journal of Physical…•2007

  • A new world of infectious disease

    Open Access•Charles F Merbs•American Journal of Physical…•1992

  • Stable nitrogen and carbon isotope ratios in bone collagen as indices of prehistoric dietary dependence on marine and terrestrial resources in Southern California

    Open Access•Phillip L Walker, Michael J Deniro•American Journal of Physical…•1986

  • Human treponematosis and tuberculosis

    Open Access•Mahmoud Y El‐najjar•American Journal of Physical…•1979

  • Brief communication

    Open Access•Darlene A Weston•American Journal of Physical…•2009

  • The Origin and Antiquity of Syphilis

    Brenda J Baker, George J Armelagos et al.•Current Anthropology•1988

  • On the possible case of treponematosis from the Bronze Age in China

    Open Access•Takao Suzuki, Takayuki Matsushita et al.•Anthropological Science•2005

  • Possible paleopathological evidence of treponematosis from a megalithic site at Agripalle, India

    Open Access•V V Rao, Vivek Rao et al.•American Journal of Physical…•1996

  • Dental defects of congenital syphilis

    Open Access•Simon Hillson, Caroline Grigson et al.•American Journal of Physical…•1998

  • Problems of dating human bones from the Iron Gates

    Open Access•Gordon Cook, G T Cook et al.•Antiquity•2002

  • Pre-Columbian congenital syphilis from the late antiquity in France

    Open Access•György Pálfi, O Dutour et al.•International Journal of…•1992

  • A pre-Columbian case of congenital syphilis from Anatolia (Nicaea, 13th century AD)

    Open Access•Y S Erdal•International Journal of…•2006

  • Pre-Columbian treponematosis in medieval Britain

    Open Access•Ann Stirland•International Journal of…•1991

  • Le crâne «romain» d'Arles

    Open Access•Bernard-Yves Mafart, Marie Antoinette Lumley et al.•Cahiers du Centre de recherches…•1998

  • The Palaeopathology of Early British Man

    Don Brothwell•The Journal of the Royal…•1961

  • Stable isotopes and the seasonality of the Oronsay middens

    Open Access•Michael Richards, M P Richard et al.•Antiquity•1998

  • Something fishy in the Neolithic? A re-evaluation of stable isotope analysis of Mesolithic and Neolithic coastal populations

    Open Access•Nicky Milner, Oliver E Craig et al.•Antiquity•2004

  • Dark Age Economics' revisited

    Open Access•James H Barrett, Alison Locker et al.•Antiquity•2004

  • Palaeopathology

    J E Buikstra, Della Collins Cook•Annual Review of Anthropology•1980

  • Scientific Integrity, Conflict of Interest and Mythology Related to Analysis of Treponematoses

    Open Access•Bruce Rothschild•Chungara•2005

  • Problems in Radiocarbon Dating Human Remains from Arid Coastal Areas

    Open Access•J Eldon Molto, Joe D Stewart et al.•American Antiquity•1997

  • The Early History of Syphilis

    Open Access•Alfred W Crosby•American Anthropologist•1969

  • Treponematosis and Man's Social Evolution

    Open Access•Ellis Herndon Hudson•American Anthropologist•1965

  • On Pseudoscience and Treponemal Disease in the Western Pacific

    Bruce M Rothschild, Bruce Rothschild et al.•Current Anthropology•1999

  • On Treponemal Disease in the Western Pacific

    Gary M Heathcote, Ann L W Stodder et al.•Current Anthropology•1998

  • Pre-Columbian Presence of Treponemal Disease

    M Steyn, M Henneberg•Current Anthropology•1995

  • On the Origin of Syphilis

    Frank B Livingstone•Current Anthropology•1991

  • Another Perspective on Acculturation and Health in Highland New Guinea

    Ann F Ramenofsky•Current Anthropology•1989

Unique citing works61
Citations per year4,36
Citation span2012 - 2026 (15)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 61

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