Estimating Telomere Length Heritability in an Unrelated Sample of Adults
Is Heritability of Telomere Length Modified by Life Course Socioeconomic Status
Bibliographic Data
| ID | 5958005 |
|---|---|
| Authors | Jessica D Faul (0000-0002-6969-6478, University of Michigan, corresponding author), C Mitchell (0000-0001-9560-1199, University of Michigan), Colter M Mitchell, Jennifer A Smith (0000-0002-3575-5468, University of Michigan), Wei Zhao (0000-0003-3892-2361, University of Michigan) |
| Year | 2016 |
| Volume | 62 |
| Issue | 1 |
| Pages | 73-86 |
| Publication date | 2016-01-02 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Biodemography and Social Biology (JOURNAL) |
| Journal identifiers | ISSN: 1948-5565 • E-ISSN: 1948-5573 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/19485565.2015.1120645 |
| PMID | 27050034 |
| OpenAlex | W2315395139 |
| Language | EN |
| Citations received | 1 |
| References cited | 56 |
Telomere length (TL) is a widely used marker of biological aging and is associated with an increased risk of morbidity and mortality. Recently, there has been evidence for an association between TL and socioeconomic status (SES), particularly for measures of education and childhood SES. Individual differences in TL are also influenced by genetic factors, with heritability estimates from twin and sibling studies ranging from 34 to 82 percent. Yet the additive heritability of TL as a result of measured genetic variations and the extent to which heritability is modified by SES is still unknown. Data from the Health and Retirement Study, a nationally representative cohort of older adults (mean age 69 years), were used to provide the first estimates of molecular-based heritability of TL using genome-wide complex trait analysis (GCTA). We found that additive genetic variance contributed 28 percent (p = .012) of total phenotypic variance of TL in the European American sample (n = 3,290). Estimation using the GCTA and KING Robust relationship inference methods did not differ significantly in this sample. None of the variance from the gene-by-SES interactions examined contributed significantly to the total TL variance. Estimation of heritability and genetic interaction with SES in the African American sample (n = 442) was too unstable to provide reliable estimates
Additive genetic effects · Biology · Health and Retirement Study · Heritability · Population · Socioeconomic status · Trait · Birth, Development, and Health · Demography · Epigenetics and DNA Methylation · Telomeres, Telomerase, and Senescence · Genetics
Technical Description of the Health and Retirement Study Sample Design
Common SNPs explain a large proportion of the heritability for human height
Gcta
Childhood socioeconomic status and adult health
Discrimination, Racial Bias, and Telomere Length in African-American Men
Cohort Profile
Telomere measurement by quantitative PCR
U.S. Disparities in Health
Genetics and intelligence differences
An Overview of the Health and Retirement Study
Low Social Support Is Associated With Shorter Leukocyte Telomere Length in Late Life
Neighborhood characteristics and leukocyte telomere length
Genetic Differential Sensitivity to Social Environments
Weathering” and Age Patterns of Allostatic Load Scores Among Blacks and Whites in the United States
The American Journal of Human Genetics
Neighborhood disorder and telomeres
Do US Black Women Experience Stress-Related Accelerated Biological Aging
Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002
Socioeconomic status and cell aging in children
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,11 |
| Citation span | 2017 - 2017 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |