Fenotipicheskie i genotipicheskie osobennosti sistemy gemostaza u sportsmenov - urozhentsev Evropeyskogo Severa
Bibliographic Data
| ID | 5967444 |
|---|---|
| Authors | N A Bushueva (Federal Scientific Center of Physical Culture and Sports), Nadezda A Vorobyeva (0000-0001-6613-2485, National Medical Research Center for Hematology) |
| Year | 2016 |
| Volume | 23 |
| Issue | 10 |
| Pages | 17-22 |
| Publication date | 2016-10-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Ekologiya Cheloveka (Human Ecology (JOURNAL) |
| Journal identifiers | ISSN: 1728-0869 • E-ISSN: 2949-1444 |
| Publisher | ECO-Vector LLC (PUBLISHER • RU) |
| DOI | 10.33396/1728-0869-2016-10-17-22 |
| OpenAlex | W2967934088 |
| Language | EN |
| Citations received | 1 |
| References cited | 6 |
Exercise is a stress factor, acting on the body, leads to changes in the hemostatic system and in particular - the fibrinolytic activity. The aim of the study was to compare the genetic characteristics of the athletes, the natives of the European north, with phenotypic markers of hemostasis. Method of sampling - continuous. The study involved athletes engaged in different sports, with sports category of the first and above, followed by the Arkhangelsk center of sports medicine. Using PCR and ELISA methods indicators of fibrinolysis and six polymorphisms of genes of the hemostatic system proteins have been evaluated. Research of hemostasiological status and genetic polymorphisms of some hemostatic system proteins in the group of athletes have revealed susceptibility to decreased activity of fibrinolysis and increase blood coagulation potential. The reason for the differences due to the higher, compared with the European, incidence of adverse associated trait in relation to polymorphisms of fibrinogen - 40.5 % in the athletes (CI: 30.3 - 51.1 %) against 20 % in the European population; platelet fibrinogen receptor - 25% (CI: 16.3 - 34.8 %) against 13 % in the European population, plasminogen activator inhibitor - 77.4 % in the athletes (CI: 67.9 - 85.7 %) against 53-61 % in the European population. A direct correlation between the presence of adverse gene polymorphism of plasminogen activator inhibitor-1 and this factor was revealed, which indicates the phenotypic expression of genetically determined depression of fibrinolysis
Biology · Coagulation · Fibrinogen · Fibrinolysis · Gene · Genotype · Hemostasis · Plasminogen activator · Population · Blood Coagulation and Thrombosis Mechanisms · Blood properties and coagulation · Medicine · Venous Thromboembolism Diagnosis and Management · Genetics · Immunology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.1 |
| Citation span | 2016 - 2016 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |