Cholesterol and Risk of Atherosclerosis in Rural Indigenous Population of Republic of Sakha (Yakutia)

According to the results of the cross-sectional study of rural indigenous population of the Republic of Sakha (Yakutia), there has been studied the level of cholesterol and frequency of atherogenic changes of the lipid profile of the blood plasma. It has been found that in 35 % of the surveyed indigenous people, the level of cholesterol was 5.2 mmol/l or more, and in 10.8 % - 6.2 mmol/l or more. Among the persons with high cholesterol, atherogenic changes of the ratio of total cholesterol / HDL-C, LDL-C / HDL-C were observed in 19 % of the men and 8 % of the women (р = 0.014); logarithm (TRG / HDL-C ) - in 11 % of the men and women (p = 0.906). Thus, the high levels of the total cholesterol (5.2 mmol /l or more) in 80 % of the men and in 89% of the women was not accompanied by atherogenic changes in the lipid profile. This allows to consider the status of hypercholesterolemia in this population group in most of the cases as a manifestation of adaptive changes in lipid metabolism. The identified changes in atherogenic lipid profile were associated with presence of metabolic risk factors, what proves the need for determination of cholesterol in lipoprotein composition and a ratio of lipid fractions for choice of a right tactics for correction of the lipid risk factors

Biology · Blood lipids · Cholesterol · Environmental health · Indigenous · Ldl cholesterol · Lipid metabolism · Lipid Profile · Population · Diet, Metabolism, and Disease · Human Health and Disease · Medicine · Nutrition, Genetics, and Disease · Ecology · Endocrinology · Internal Medicine

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